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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PASK_HUMAN (Q96RG2)

Summary

This is the summary of UniProt entry PASK_HUMAN (Q96RG2).

Description: PAS domain-containing serine/threonine-protein kinase EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1323 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 3
disorder n/a 20 21
disorder n/a 26 45
disorder n/a 90 96
low_complexity n/a 102 122
Pfam PAS_9 131 233
low_complexity n/a 309 320
disorder n/a 322 328
Pfam PAS_9 345 414
disorder n/a 419 437
disorder n/a 459 460
disorder n/a 476 477
disorder n/a 483 561
disorder n/a 579 580
disorder n/a 584 591
disorder n/a 631 638
disorder n/a 644 645
disorder n/a 647 649
low_complexity n/a 696 709
disorder n/a 759 761
disorder n/a 770 779
disorder n/a 785 786
disorder n/a 840 866
Pfam Pkinase 999 1251
low_complexity n/a 1018 1036
disorder n/a 1294 1321

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96RG2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEDGGLTAFE EDQRCLSQSL PLPVSAEGPA AQTTAEPSRS FSSAHRHLSR
50
51
RNGLSRLCQS RTALSEDRWS SYCLSSLAAQ NICTSKLHCP AAPEHTDPSE
100
101
PRGSVSCCSL LRGLSSGWSS PLLPAPVCNP NKAIFTVDAK TTEILVANDK
150
151
ACGLLGYSSQ DLIGQKLTQF FLRSDSDVVE ALSEEHMEAD GHAAVVFGTV
200
201
VDIISRSGEK IPVSVWMKRM RQERRLCCVV VLEPVERVST WVAFQSDGTV
250
251
TSCDSLFAHL HGYVSGEDVA GQHITDLIPS VQLPPSGQHI PKNLKIQRSV
300
301
GRARDGTTFP LSLKLKSQPS SEEATTGEAA PVSGYRASVW VFCTISGLIT
350
351
LLPDGTIHGI NHSFALTLFG YGKTELLGKN ITFLIPGFYS YMDLAYNSSL
400
401
QLPDLASCLD VGNESGCGER TLDPWQGQDP AEGGQDPRIN VVLAGGHVVP
450
451
RDEIRKLMES QDIFTGTQTE LIAGGQLLSC LSPQPAPGVD NVPEGSLPVH
500
501
GEQALPKDQQ ITALGREEPV AIESPGQDLL GESRSEPVDV KPFASCEDSE
550
551
APVPAEDGGS DAGMCGLCQK AQLERMGVSG PSGSDLWAGA AVAKPQAKGQ
600
601
LAGGSLLMHC PCYGSEWGLW WRSQDLAPSP SGMAGLSFGT PTLDEPWLGV
650
651
ENDREELQTC LIKEQLSQLS LAGALDVPHA ELVPTECQAV TAPVSSCDLG
700
701
GRDLCGGCTG SSSACYALAT DLPGGLEAVE AQEVDVNSFS WNLKELFFSD
750
751
QTDQTSSNCS CATSELRETP SSLAVGSDPD VGSLQEQGSC VLDDRELLLL
800
801
TGTCVDLGQG RRFRESCVGH DPTEPLEVCL VSSEHYAASD RESPGHVPST
850
851
LDAGPEDTCP SAEEPRLNVQ VTSTPVIVMR GAAGLQREIQ EGAYSGSCYH
900
901
RDGLRLSIQF EVRRVELQGP TPLFCCWLVK DLLHSQRDSA ARTRLFLASL
950
951
PGSTHSTAAE LTGPSLVEVL RARPWFEEPP KAVELEGLAA CEGEYSQKYS
1000
1001
TMSPLGSGAF GFVWTAVDKE KNKEVVVKFI KKEKVLEDCW IEDPKLGKVT
1050
1051
LEIAILSRVE HANIIKVLDI FENQGFFQLV MEKHGSGLDL FAFIDRHPRL
1100
1101
DEPLASYIFR QLVSAVGYLR LKDIIHRDIK DENIVIAEDF TIKLIDFGSA
1150
1151
AYLERGKLFY TFCGTIEYCA PEVLMGNPYR GPELEMWSLG VTLYTLVFEE
1200
1201
NPFCELEETV EAAIHPPYLV SKELMSLVSG LLQPVPERRT TLEKLVTDPW
1250
1251
VTQPVNLADY TWEEVFRVNK PESGVLSAAS LEMGNRSLSD VAQAQELCGG
1300
1301
PVPGEAPNGQ GCLHPGDPRL LTS                             
1323
 

Show the unformatted sequence.

Checksums:
CRC64:F8A3633CC6F6C8CD
MD5:306a5f50d2ab1d0b3693279eab13c5a0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PAS_9 131 - 233 1LL8 A 8 - 110 Jmol OpenAstexViewer
Pkinase 999 - 1251 3DLS A 999 - 1251 Jmol OpenAstexViewer
B 999 - 1251 Jmol OpenAstexViewer
C 999 - 1251 Jmol OpenAstexViewer
D 999 - 1251 Jmol OpenAstexViewer
E 999 - 1251 Jmol OpenAstexViewer
F 999 - 1251 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.