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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RUFY1_HUMAN (Q96T51)

Summary

This is the summary of UniProt entry RUFY1_HUMAN (Q96T51).

Description: RUN and FYVE domain-containing protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 708 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 57
low_complexity n/a 1 16
low_complexity n/a 9 34
low_complexity n/a 77 104
disorder n/a 92 107
Pfam RUN 147 270
low_complexity n/a 245 261
coiled_coil n/a 322 349
low_complexity n/a 352 369
coiled_coil n/a 353 373
disorder n/a 362 365
disorder n/a 371 372
disorder n/a 390 391
low_complexity n/a 404 422
disorder n/a 432 440
coiled_coil n/a 435 455
disorder n/a 449 450
disorder n/a 470 525
coiled_coil n/a 470 490
coiled_coil n/a 498 525
coiled_coil n/a 530 571
low_complexity n/a 544 555
disorder n/a 546 570
disorder n/a 572 574
coiled_coil n/a 575 612
disorder n/a 576 577
disorder n/a 586 587
disorder n/a 614 615
Pfam FYVE 637 701

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96T51. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADREGGCAA GRGRELEPEL EPGPGPGSAL EPGEEFEIVD RSQLPGPGDL
50
51
RSATRPRAAE GWSAPILTLA RRATGNLSAS CGSALRAAAG LGGGDSGDGT
100
101
ARAASKCQMM EERANLMHMM KLSIKVLLQS ALSLGRSLDA DHAPLQQFFV
150
151
VMEHCLKHGL KVKKSFIGQN KSFFGPLELV EKLCPEASDI ATSVRNLPEL
200
201
KTAVGRGRAW LYLALMQKKL ADYLKVLIDN KHLLSEFYEP EALMMEEEGM
250
251
VIVGLLVGLN VLDANLCLKG EDLDSQVGVI DFSLYLKDVQ DLDGGKEHER
300
301
ITDVLDQKNY VEELNRHLSC TVGDLQTKID GLEKTNSKLQ EELSAATDRI
350
351
CSLQEEQQQL REQNELIRER SEKSVEITKQ DTKVELETYK QTRQGLDEMY
400
401
SDVWKQLKEE KKVRLELEKE LELQIGMKTE MEIAMKLLEK DTHEKQDTLV
450
451
ALRQQLEEVK AINLQMFHKA QNAESSLQQK NEAITSFEGK TNQVMSSMKQ
500
501
MEERLQHSER ARQGAEERSH KLQQELGGRI GALQLQLSQL HEQCSSLEKE
550
551
LKSEKEQRQA LQRELQHEKD TSSLLRMELQ QVEGLKKELR ELQDEKAELQ
600
601
KICEEQEQAL QEMGLHLSQS KLKMEDIKEV NQALKGHAWL KDDEATHCRQ
650
651
CEKEFSISRR KHHCRNCGHI FCNTCSSNEL ALPSYPKPVR VCDSCHTLLL
700
701
QRCSSTAS                                              
708
 

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Checksums:
CRC64:6697B4BC108AD54F
MD5:acaf9da1d3978823376c6332cbf4c10e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FYVE 637 - 701 2YQM A 18 - 82 Jmol OpenAstexViewer
641 - 701 2YW8 A 15 - 75 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.