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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DNJC2_HUMAN (Q99543)

Summary

This is the summary of UniProt entry DNJC2_HUMAN (Q99543).

Description: DnaJ homolog subfamily C member 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 621 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
coiled_coil n/a 43 63
disorder n/a 49 67
low_complexity n/a 51 72
disorder n/a 70 72
Pfam DnaJ 88 158
disorder n/a 111 129
disorder n/a 165 166
disorder n/a 196 199
coiled_coil n/a 230 250
low_complexity n/a 231 245
disorder n/a 241 264
coiled_coil n/a 280 359
low_complexity n/a 281 321
disorder n/a 287 324
low_complexity n/a 312 336
disorder n/a 331 337
low_complexity n/a 338 352
Pfam RAC_head 339 430
disorder n/a 342 344
disorder n/a 347 351
disorder n/a 359 372
disorder n/a 374 375
coiled_coil n/a 408 439
disorder n/a 417 453
low_complexity n/a 423 432
low_complexity n/a 437 453
Pfam Myb_DNA-binding 451 507
disorder n/a 500 550
Pfam Myb_DNA-binding 552 600
disorder n/a 576 584
disorder n/a 610 621

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99543. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF
50
51
QELEDKKELS EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY
100
101
KATQRQIKAA HKAMVLKHHP DKRKAAGEPI KEGDNDYFTC ITKAYEMLSD
150
151
PVKRRAFNSV DPTFDNSVPS KSEAKDNFFE VFTPVFERNS RWSNKKNVPK
200
201
LGDMNSSFED VDIFYSFWYN FDSWREFSYL DEEEKEKAEC RDERRWIEKQ
250
251
NRATRAQRKK EEMNRIRTLV DNAYSCDPRI KKFKEEEKAK KEAEKKAKAE
300
301
AKRKEQEAKE KQRQAELEAA RLAKEKEEEE VRQQALLAKK EKDIQKKAIK
350
351
KERQKLRNSC KTWNHFSDNE AERVKMMEEV EKLCDRLELA SLQCLNETLT
400
401
SCTKEVGKAA LEKQIEEINE QIRKEKEEAE ARMRQASKNT EKSTGGGGNG
450
451
SKNWSEDDLQ LLIKAVNLFP AGTNSRWEVI ANYMNIHSSS GVKRTAKDVI
500
501
GKAKSLQKLD PHQKDDINKK AFDKFKKEHG VVPQADNATP SERFEGPYTD
550
551
FTPWTTEEQK LLEQALKTYP VNTPERWEKI AEAVPGRTKK DCMKRYKELV
600
601
EMVKAKKAAQ EQVLNASRAK K                               
621
 

Show the unformatted sequence.

Checksums:
CRC64:E4DAEE7A73D0F64C
MD5:cbb6cf981321ac990ae18ab68899eddd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Myb_DNA-binding 552 - 600 2M2E A 552 - 600 Show 3D Structure View in InterPro
RAC_head 346 - 430 6CGH A 346 - 430 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;