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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TBX5_HUMAN (Q99593)

Summary

This is the summary of UniProt entry TBX5_HUMAN (Q99593).

Description: T-box transcription factor TBX5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 518 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 7 10
disorder n/a 15 46
low_complexity n/a 33 44
Pfam T-box 56 238
disorder n/a 134 136
disorder n/a 228 230
disorder n/a 236 281
disorder n/a 285 320
low_complexity n/a 303 313
disorder n/a 322 328
disorder n/a 332 370
disorder n/a 375 386
low_complexity n/a 380 391
disorder n/a 391 396
disorder n/a 437 458
disorder n/a 461 490
disorder n/a 500 502
disorder n/a 506 510
disorder n/a 513 518

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99593. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADADEGFGL AHTPLEPDAK DLPCDSKPES ALGAPSKSPS SPQAAFTQQG
50
51
MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY
100
101
ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR
150
151
QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA
200
201
FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM
250
251
QSKEYPVVPR STVRQKVASN HSPFSSESRA LSTSSNLGSQ YQCENGVSGP
300
301
SQDLLPPPNP YPLPQEHSQI YHCTKRKEEE CSTTDHPYKK PYMETSPSEE
350
351
DSFYRSSYPQ QQGLGASYRT ESAQRQACMY ASSAPPSEPV PSLEDISCNT
400
401
WPSMPSYSSC TVTTVQPMDR LPYQHFSAHF TSGPLVPRLA GMANHGSPQL
450
451
GEGMFQHQTS VAHQPVVRQC GPQTGLQSPG TLQPPEFLYS HGVPRTLSPH
500
501
QYHSVHGVGM VPEWSDNS                                   
518
 

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Checksums:
CRC64:70118AD84FF5C00F
MD5:ad822af3bc565c55f8b350715008edb5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
T-box 56 - 230 2X6U A 56 - 230 Jmol OpenAstexViewer
5BQD B 56 - 230 Jmol OpenAstexViewer
56 - 232 2X6V B 56 - 232 Jmol OpenAstexViewer
5BQD A 56 - 232 Jmol OpenAstexViewer
56 - 238 2X6V A 56 - 238 Jmol OpenAstexViewer
4S0H A 56 - 238 Jmol OpenAstexViewer
E 56 - 238 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.