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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EIF3C_HUMAN (Q99613)

Summary

This is the summary of UniProt entry EIF3C_HUMAN (Q99613).

Description: Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 913 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 3 5
low_complexity n/a 7 21
disorder n/a 9 10
disorder n/a 15 24
Pfam eIF-3c_N 29 705
disorder n/a 34 36
low_complexity n/a 126 136
disorder n/a 128 129
disorder n/a 131 136
disorder n/a 152 306
low_complexity n/a 174 189
low_complexity n/a 215 246
low_complexity n/a 264 287
coiled_coil n/a 275 295
low_complexity n/a 289 301
low_complexity n/a 296 307
disorder n/a 459 461
disorder n/a 466 467
disorder n/a 522 540
low_complexity n/a 643 657
disorder n/a 661 667
Pfam PCI 712 846
disorder n/a 725 726
disorder n/a 731 732
disorder n/a 838 840
disorder n/a 842 847
disorder n/a 885 886
disorder n/a 895 907
disorder n/a 909 913

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99613. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR
50
51
SAKDKRFEEL TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE
100
101
GVPRFYIRIL ADLEDYLNEL WEDKEGKKKM NKNNAKALST LRQKIRKYNR
150
151
DFESHITSYK QNPEQSADED AEKNEEDSEG SSDEDEDEDG VSAATFLKKK
200
201
SEAPSGESRK FLKKMDDEDE DSEDSEDDED WDTGSTSSDS DSEEEEGKQT
250
251
ALASRFLKKA PTTDEDKKAA EKKREDKAKK KHDRKSKRLD EEEEDNEGGE
300
301
WERVRGGVPL VKEKPKMFAK GTEITHAVVI KKLNEILQAR GKKGTDRAAQ
350
351
IELLQLLVQI AAENNLGEGV IVKIKFNIIA SLYDYNPNLA TYMKPEMWGK
400
401
CLDCINELMD ILFANPNIFV GENILEESEN LHNADQPLRV RGCILTLVER
450
451
MDEEFTKIMQ NTDPHSQEYV EHLKDEAQVC AIIERVQRYL EEKGTTEEVC
500
501
RIYLLRILHT YYKFDYKAHQ RQLTPPEGSS KSEQDQAENE GEDSAVLMER
550
551
LCKYIYAKDR TDRIRTCAIL CHIYHHALHS RWYQARDLML MSHLQDNIQH
600
601
ADPPVQILYN RTMVQLGICA FRQGLTKDAH NALLDIQSSG RAKELLGQGL
650
651
LLRSLQERNQ EQEKVERRRQ VPFHLHINLE LLECVYLVSA MLLEIPYMAA
700
701
HESDARRRMI SKQFHHQLRV GERQPLLGPP ESMREHVVAA SKAMKMGDWK
750
751
TCHSFIINEK MNGKVWDLFP EADKVRTMLV RKIQEESLRT YLFTYSSVYD
800
801
SISMETLSDM FELDLPTVHS IISKMIINEE LMASLDQPTQ TVVMHRTEPT
850
851
AQQNLALQLA EKLGSLVENN ERVFDHKQGT YGGYFRDQKD GYRKNEGYMR
900
901
RGGYRQQQSQ TAY                                        
913
 

Show the unformatted sequence.

Checksums:
CRC64:CE5029F4EB51C1AA
MD5:91f98692a03d34585834db48960afb8a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
eIF-3c_N 326 - 705 3J8B C 116 - 495 Jmol OpenAstexViewer
3J8C C 116 - 495 Jmol OpenAstexViewer
PCI 712 - 846 3J8B C 502 - 636 Jmol OpenAstexViewer
3J8C C 502 - 636 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.