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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PITX2_HUMAN (Q99697)

Summary

This is the summary of UniProt entry PITX2_HUMAN (Q99697).

Description: Pituitary homeobox 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 317 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 35 41
disorder n/a 43 97
Pfam Homeodomain 86 142
disorder n/a 99 100
disorder n/a 103 106
disorder n/a 143 155
low_complexity n/a 206 229
low_complexity n/a 237 255
low_complexity n/a 256 273
Pfam OAR 275 293

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99697. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS
50
51
KFFPRQHPGA NEKDKSQQGK NEDVGAEDPS KKKRQRRQRT HFTSQQLQEL
100
101
EATFQRNRYP DMSTREEIAV WTNLTEARVR VWFKNRRAKW RKRERNQQAE
150
151
LCKNGFGPQF NGLMQPYDDM YPGYSYNNWA AKGLTSASLS TKSFPFFNSM
200
201
NVNPLSSQSM FSPPNSISSM SMSSSMVPSA VTGVPGSSLN SLNNLNNLSS
250
251
PSLNSAVPTP ACPYAPPTPP YVYRDTCNSS LASLRLKAKQ HSSFGYASVQ
300
301
NPASNLSACQ YAVDRPV                                    
317
 

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Checksums:
CRC64:00853AFDBA4433CB
MD5:5816e076e8387ec77bc94cca8840ff22

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Homeodomain 86 - 142 2L7F P 2 - 58 NGL View in InterPro
2L7M P 2 - 58 NGL View in InterPro
2LKX A 2 - 58 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.