Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TS101_HUMAN (Q99816)

Summary

This is the summary of UniProt entry TS101_HUMAN (Q99816).

Description: Tumor susceptibility gene 101 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 390 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam UEV 21 141
disorder n/a 146 149
disorder n/a 154 155
disorder n/a 157 162
low_complexity n/a 161 196
disorder n/a 164 228
coiled_coil n/a 239 311
disorder n/a 241 246
disorder n/a 248 272
disorder n/a 274 276
disorder n/a 299 306
disorder n/a 312 313
Pfam Vps23_core 316 379

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99816. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR
50
51
ELMNLTGTIP VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG
100
101
KHVDANGKIY LPYLHEWKHP QSDLLGLIQV MIVVFGDEPP VFSRPISASY
150
151
PPYQATGPPN TSYMPGMPGG ISPYPSGYPP NPSGYPGCPY PPGGPYPATT
200
201
SSQYPSQPPV TTVGPSRDGT ISEDTIRASL ISAVSDKLRW RMKEEMDRAQ
250
251
AELNALKRTE EDLKKGHQKL EEMVTRLDQE VAEVDKNIEL LKKKDEELSS
300
301
ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR
350
351
RGVIDLDVFL KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY           
390
 

Show the unformatted sequence.

Checksums:
CRC64:ADD6912FC22DF162
MD5:4230cb48200a4aead4ee6b7d3b5c1799

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
UEV 21 - 141 1KPP A 21 - 141 Jmol OpenAstexViewer
1KPQ A 21 - 141 Jmol OpenAstexViewer
1M4P A 21 - 141 Jmol OpenAstexViewer
1M4Q A 21 - 141 Jmol OpenAstexViewer
1S1Q A 21 - 141 Jmol OpenAstexViewer
C 21 - 141 Jmol OpenAstexViewer
2F0R A 21 - 141 Jmol OpenAstexViewer
B 21 - 141 Jmol OpenAstexViewer
3OBQ A 21 - 141 Jmol OpenAstexViewer
3OBS A 21 - 141 Jmol OpenAstexViewer
3OBU A 21 - 141 Jmol OpenAstexViewer
3OBX A 21 - 141 Jmol OpenAstexViewer
3P9G A 21 - 141 Jmol OpenAstexViewer
3P9H A 21 - 141 Jmol OpenAstexViewer
4EJE A 21 - 141 Jmol OpenAstexViewer
B 21 - 141 Jmol OpenAstexViewer
4YC1 A 21 - 141 Jmol OpenAstexViewer
B 21 - 141 Jmol OpenAstexViewer
C 21 - 141 Jmol OpenAstexViewer
4ZNY A 21 - 141 Jmol OpenAstexViewer
5VKG A 21 - 141 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.