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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TS101_HUMAN (Q99816)

Summary

This is the summary of UniProt entry TS101_HUMAN (Q99816).

Description: Tumor susceptibility gene 101 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 390 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam UEV 21 141
disorder n/a 146 149
disorder n/a 154 155
disorder n/a 157 162
low_complexity n/a 162 197
disorder n/a 164 228
coiled_coil n/a 239 311
disorder n/a 241 246
disorder n/a 248 272
disorder n/a 274 276
disorder n/a 299 306
disorder n/a 312 313
Pfam Vps23_core 316 379

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99816. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR
50
51
ELMNLTGTIP VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG
100
101
KHVDANGKIY LPYLHEWKHP QSDLLGLIQV MIVVFGDEPP VFSRPISASY
150
151
PPYQATGPPN TSYMPGMPGG ISPYPSGYPP NPSGYPGCPY PPGGPYPATT
200
201
SSQYPSQPPV TTVGPSRDGT ISEDTIRASL ISAVSDKLRW RMKEEMDRAQ
250
251
AELNALKRTE EDLKKGHQKL EEMVTRLDQE VAEVDKNIEL LKKKDEELSS
300
301
ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR
350
351
RGVIDLDVFL KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY           
390
 

Show the unformatted sequence.

Checksums:
CRC64:ADD6912FC22DF162
MD5:4230cb48200a4aead4ee6b7d3b5c1799

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
UEV 21 - 141 1KPP A 21 - 141 Show 3D Structure View in InterPro
1KPQ A 21 - 141 Show 3D Structure View in InterPro
1M4P A 21 - 141 Show 3D Structure View in InterPro
1M4Q A 21 - 141 Show 3D Structure View in InterPro
1S1Q A 21 - 141 Show 3D Structure View in InterPro
C 21 - 141 Show 3D Structure View in InterPro
2F0R A 21 - 141 Show 3D Structure View in InterPro
B 21 - 141 Show 3D Structure View in InterPro
3OBQ A 21 - 141 Show 3D Structure View in InterPro
3OBS A 21 - 141 Show 3D Structure View in InterPro
3OBU A 21 - 141 Show 3D Structure View in InterPro
3OBX A 21 - 141 Show 3D Structure View in InterPro
3P9G A 21 - 141 Show 3D Structure View in InterPro
3P9H A 21 - 141 Show 3D Structure View in InterPro
4EJE A 21 - 141 Show 3D Structure View in InterPro
B 21 - 141 Show 3D Structure View in InterPro
4YC1 A 21 - 141 Show 3D Structure View in InterPro
B 21 - 141 Show 3D Structure View in InterPro
C 21 - 141 Show 3D Structure View in InterPro
4ZNY A 21 - 141 Show 3D Structure View in InterPro
5VKG A 21 - 141 Show 3D Structure View in InterPro
6UD0 C 21 - 141 Show 3D Structure View in InterPro
Vps23_core 316 - 379 6VME B 316 - 379 Show 3D Structure View in InterPro
F 316 - 379 Show 3D Structure View in InterPro
G 316 - 379 Show 3D Structure View in InterPro
H 316 - 379 Show 3D Structure View in InterPro
I 316 - 379 Show 3D Structure View in InterPro
J 316 - 379 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;