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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SMO_HUMAN (Q99835)

Summary

This is the summary of UniProt entry SMO_HUMAN (Q99835).

Description: Smoothened homolog
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 787 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 3
sig_p n/a 1 31
low_complexity n/a 2 31
disorder n/a 30 58
low_complexity n/a 38 53
Pfam Fz 70 178
disorder n/a 93 94
Pfam Frizzled 221 552
transmembrane n/a 233 254
transmembrane n/a 266 283
transmembrane n/a 315 339
transmembrane n/a 359 379
transmembrane n/a 399 420
transmembrane n/a 452 475
transmembrane n/a 520 538
disorder n/a 637 645
low_complexity n/a 639 648
disorder n/a 648 649
disorder n/a 653 655
disorder n/a 666 706
low_complexity n/a 667 680
low_complexity n/a 684 698
disorder n/a 732 787

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99835. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR
50
51
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE
100
101
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT
150
151
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT
200
201
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA
250
251
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT
300
301
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY
350
351
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR
400
401
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML
450
451
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT
500
501
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC
550
551
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV
600
601
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE
650
651
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST
700
701
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP
750
751
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF              
787
 

Show the unformatted sequence.

Checksums:
CRC64:8B4C459B34D13F83
MD5:c2bd4bb53855cb388a8159176bc9647e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Frizzled 221 - 538 6XBJ R 221 - 538 Show 3D Structure View in InterPro
6XBK R 221 - 538 Show 3D Structure View in InterPro
6XBL R 221 - 538 Show 3D Structure View in InterPro
6XBM R 221 - 538 Show 3D Structure View in InterPro
221 - 550 4JKV A 221 - 550 Show 3D Structure View in InterPro
221 - 551 4O9R A 221 - 551 Show 3D Structure View in InterPro
4QIN A 221 - 551 Show 3D Structure View in InterPro
5L7D B 221 - 551 Show 3D Structure View in InterPro
5L7I A 221 - 551 Show 3D Structure View in InterPro
221 - 552 4JKV B 221 - 552 Show 3D Structure View in InterPro
4N4W A 221 - 552 Show 3D Structure View in InterPro
4QIM A 221 - 552 Show 3D Structure View in InterPro
5L7D A 221 - 552 Show 3D Structure View in InterPro
5L7I B 221 - 552 Show 3D Structure View in InterPro
5V56 A 221 - 552 Show 3D Structure View in InterPro
B 221 - 552 Show 3D Structure View in InterPro
5V57 A 221 - 552 Show 3D Structure View in InterPro
B 221 - 552 Show 3D Structure View in InterPro
6OT0 R 221 - 552 Show 3D Structure View in InterPro
Fz 70 - 178 5L7D A 70 - 178 Show 3D Structure View in InterPro
B 70 - 178 Show 3D Structure View in InterPro
5L7I A 70 - 178 Show 3D Structure View in InterPro
B 70 - 178 Show 3D Structure View in InterPro
5V56 A 70 - 178 Show 3D Structure View in InterPro
B 70 - 178 Show 3D Structure View in InterPro
5V57 A 70 - 178 Show 3D Structure View in InterPro
B 70 - 178 Show 3D Structure View in InterPro
6XBJ R 70 - 178 Show 3D Structure View in InterPro
6XBK R 70 - 178 Show 3D Structure View in InterPro
6XBL R 70 - 178 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;