Summary
This is the summary of UniProt entry SMO_HUMAN (Q99835).
| Description: | Smoothened homolog |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 787 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 3 |
| sig_p | n/a | 1 | 31 |
| low_complexity | n/a | 2 | 31 |
| disorder | n/a | 30 | 58 |
| low_complexity | n/a | 38 | 53 |
| Pfam | Fz | 70 | 178 |
| disorder | n/a | 93 | 94 |
| Pfam | Frizzled | 221 | 552 |
| transmembrane | n/a | 233 | 254 |
| transmembrane | n/a | 266 | 283 |
| transmembrane | n/a | 315 | 339 |
| transmembrane | n/a | 359 | 379 |
| transmembrane | n/a | 399 | 420 |
| transmembrane | n/a | 452 | 475 |
| transmembrane | n/a | 520 | 538 |
| disorder | n/a | 637 | 645 |
| low_complexity | n/a | 639 | 648 |
| disorder | n/a | 648 | 649 |
| disorder | n/a | 653 | 655 |
| disorder | n/a | 666 | 706 |
| low_complexity | n/a | 667 | 680 |
| low_complexity | n/a | 684 | 698 |
| disorder | n/a | 732 | 787 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q99835. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR
50 51
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE
100 101
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT
150 151
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT
200 201
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA
250 251
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT
300 301
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY
350 351
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR
400 401
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML
450 451
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT
500 501
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC
550 551
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV
600 601
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE
650 651
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST
700 701
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP
750 751
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF
787
Show the unformatted sequence. |
| Checksums: |
CRC64:8B4C459B34D13F83
MD5:c2bd4bb53855cb388a8159176bc9647e
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
