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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SMO_HUMAN (Q99835)

Summary

This is the summary of UniProt entry SMO_HUMAN (Q99835).

Description: Smoothened homolog
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 787 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 3
sig_p n/a 1 31
low_complexity n/a 1 30
disorder n/a 30 58
low_complexity n/a 37 52
Pfam Fz 70 179
disorder n/a 93 94
Pfam Frizzled 221 552
transmembrane n/a 233 254
transmembrane n/a 266 283
transmembrane n/a 315 339
transmembrane n/a 359 379
transmembrane n/a 399 420
transmembrane n/a 452 475
transmembrane n/a 520 538
disorder n/a 637 645
low_complexity n/a 638 647
disorder n/a 648 649
disorder n/a 653 655
disorder n/a 666 706
low_complexity n/a 666 679
low_complexity n/a 683 697
disorder n/a 732 787

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99835. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR
50
51
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE
100
101
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT
150
151
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT
200
201
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA
250
251
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT
300
301
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY
350
351
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR
400
401
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML
450
451
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT
500
501
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC
550
551
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV
600
601
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE
650
651
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST
700
701
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP
750
751
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF              
787
 

Show the unformatted sequence.

Checksums:
CRC64:8B4C459B34D13F83
MD5:c2bd4bb53855cb388a8159176bc9647e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Frizzled 221 - 550 4JKV A 221 - 550 Jmol OpenAstexViewer
221 - 551 4O9R A 221 - 551 Jmol OpenAstexViewer
4QIN A 221 - 551 Jmol OpenAstexViewer
5L7D B 221 - 551 Jmol OpenAstexViewer
5L7I A 221 - 551 Jmol OpenAstexViewer
221 - 552 4JKV B 221 - 552 Jmol OpenAstexViewer
4N4W A 221 - 552 Jmol OpenAstexViewer
4QIM A 221 - 552 Jmol OpenAstexViewer
5L7D A 221 - 552 Jmol OpenAstexViewer
5L7I B 221 - 552 Jmol OpenAstexViewer
5V56 A 221 - 552 Jmol OpenAstexViewer
B 221 - 552 Jmol OpenAstexViewer
5V57 A 221 - 552 Jmol OpenAstexViewer
B 221 - 552 Jmol OpenAstexViewer
6OT0 R 221 - 552 Jmol OpenAstexViewer
Fz 70 - 179 5L7D A 70 - 179 Jmol OpenAstexViewer
B 70 - 179 Jmol OpenAstexViewer
5L7I A 70 - 179 Jmol OpenAstexViewer
B 70 - 179 Jmol OpenAstexViewer
5V56 A 70 - 179 Jmol OpenAstexViewer
B 70 - 179 Jmol OpenAstexViewer
5V57 A 70 - 179 Jmol OpenAstexViewer
B 70 - 179 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.