Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CAS9_STRP1 (Q99ZW2)

Summary

This is the summary of UniProt entry CAS9_STRP1 (Q99ZW2).

Description: CRISPR-associated endonuclease Cas9/Csn1 {ECO:0000255|HAMAP-Rule:MF_01480}
Source organism: Streptococcus pyogenes serotype M1 (NCBI taxonomy ID 301447)
View Pfam proteome data.
Length: 1368 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
low_complexity n/a 57 77
Pfam Cas9-BH 62 94
disorder n/a 64 67
Pfam Cas9_REC 181 712
low_complexity n/a 604 618
disorder n/a 719 721
disorder n/a 724 725
disorder n/a 759 784
disorder n/a 798 800
Pfam HNH_4 821 872
disorder n/a 857 871
Pfam Cas9_PI 1102 1358
low_complexity n/a 1147 1164

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q99ZW2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDKKYSIGLD IGTNSVGWAV ITDEYKVPSK KFKVLGNTDR HSIKKNLIGA
50
51
LLFDSGETAE ATRLKRTARR RYTRRKNRIC YLQEIFSNEM AKVDDSFFHR
100
101
LEESFLVEED KKHERHPIFG NIVDEVAYHE KYPTIYHLRK KLVDSTDKAD
150
151
LRLIYLALAH MIKFRGHFLI EGDLNPDNSD VDKLFIQLVQ TYNQLFEENP
200
201
INASGVDAKA ILSARLSKSR RLENLIAQLP GEKKNGLFGN LIALSLGLTP
250
251
NFKSNFDLAE DAKLQLSKDT YDDDLDNLLA QIGDQYADLF LAAKNLSDAI
300
301
LLSDILRVNT EITKAPLSAS MIKRYDEHHQ DLTLLKALVR QQLPEKYKEI
350
351
FFDQSKNGYA GYIDGGASQE EFYKFIKPIL EKMDGTEELL VKLNREDLLR
400
401
KQRTFDNGSI PHQIHLGELH AILRRQEDFY PFLKDNREKI EKILTFRIPY
450
451
YVGPLARGNS RFAWMTRKSE ETITPWNFEE VVDKGASAQS FIERMTNFDK
500
501
NLPNEKVLPK HSLLYEYFTV YNELTKVKYV TEGMRKPAFL SGEQKKAIVD
550
551
LLFKTNRKVT VKQLKEDYFK KIECFDSVEI SGVEDRFNAS LGTYHDLLKI
600
601
IKDKDFLDNE ENEDILEDIV LTLTLFEDRE MIEERLKTYA HLFDDKVMKQ
650
651
LKRRRYTGWG RLSRKLINGI RDKQSGKTIL DFLKSDGFAN RNFMQLIHDD
700
701
SLTFKEDIQK AQVSGQGDSL HEHIANLAGS PAIKKGILQT VKVVDELVKV
750
751
MGRHKPENIV IEMARENQTT QKGQKNSRER MKRIEEGIKE LGSQILKEHP
800
801
VENTQLQNEK LYLYYLQNGR DMYVDQELDI NRLSDYDVDH IVPQSFLKDD
850
851
SIDNKVLTRS DKNRGKSDNV PSEEVVKKMK NYWRQLLNAK LITQRKFDNL
900
901
TKAERGGLSE LDKAGFIKRQ LVETRQITKH VAQILDSRMN TKYDENDKLI
950
951
REVKVITLKS KLVSDFRKDF QFYKVREINN YHHAHDAYLN AVVGTALIKK
1000
1001
YPKLESEFVY GDYKVYDVRK MIAKSEQEIG KATAKYFFYS NIMNFFKTEI
1050
1051
TLANGEIRKR PLIETNGETG EIVWDKGRDF ATVRKVLSMP QVNIVKKTEV
1100
1101
QTGGFSKESI LPKRNSDKLI ARKKDWDPKK YGGFDSPTVA YSVLVVAKVE
1150
1151
KGKSKKLKSV KELLGITIME RSSFEKNPID FLEAKGYKEV KKDLIIKLPK
1200
1201
YSLFELENGR KRMLASAGEL QKGNELALPS KYVNFLYLAS HYEKLKGSPE
1250
1251
DNEQKQLFVE QHKHYLDEII EQISEFSKRV ILADANLDKV LSAYNKHRDK
1300
1301
PIREQAENII HLFTLTNLGA PAAFKYFDTT IDRKRYTSTK EVLDATLIHQ
1350
1351
SITGLYETRI DLSQLGGD                                   
1368
 

Show the unformatted sequence.

Checksums:
CRC64:07D04F0B5965762F
MD5:1288627a192ce7489830765ba4f57576

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cas9-BH 62 - 94 4CMP A 62 - 94 Jmol OpenAstexViewer
B 62 - 94 Jmol OpenAstexViewer
4CMQ A 62 - 94 Jmol OpenAstexViewer
B 62 - 94 Jmol OpenAstexViewer
4OO8 A 62 - 94 Jmol OpenAstexViewer
D 62 - 94 Jmol OpenAstexViewer
4UN3 B 62 - 94 Jmol OpenAstexViewer
4UN4 B 62 - 94 Jmol OpenAstexViewer
4UN5 B 62 - 94 Jmol OpenAstexViewer
4ZT0 A 62 - 94 Jmol OpenAstexViewer
C 62 - 94 Jmol OpenAstexViewer
4ZT9 A 62 - 94 Jmol OpenAstexViewer
C 62 - 94 Jmol OpenAstexViewer
5B2R B 62 - 94 Jmol OpenAstexViewer
5B2S B 62 - 94 Jmol OpenAstexViewer
5B2T B 62 - 94 Jmol OpenAstexViewer
5F9R B 62 - 94 Jmol OpenAstexViewer
5FQ5 B 62 - 94 Jmol OpenAstexViewer
5FW1 B 62 - 94 Jmol OpenAstexViewer
5FW2 B 62 - 94 Jmol OpenAstexViewer
5FW3 B 62 - 94 Jmol OpenAstexViewer
Cas9_PI 1102 - 1358 4CMP A 1102 - 1358 Jmol OpenAstexViewer
B 1102 - 1358 Jmol OpenAstexViewer
4CMQ A 1102 - 1358 Jmol OpenAstexViewer
B 1102 - 1358 Jmol OpenAstexViewer
4OO8 A 1102 - 1358 Jmol OpenAstexViewer
D 1102 - 1358 Jmol OpenAstexViewer
4UN3 B 1102 - 1358 Jmol OpenAstexViewer
4UN4 B 1102 - 1358 Jmol OpenAstexViewer
4UN5 B 1102 - 1358 Jmol OpenAstexViewer
4ZT0 A 1102 - 1358 Jmol OpenAstexViewer
C 1102 - 1358 Jmol OpenAstexViewer
4ZT9 A 1102 - 1358 Jmol OpenAstexViewer
C 1102 - 1358 Jmol OpenAstexViewer
5B2R B 1102 - 1358 Jmol OpenAstexViewer
5B2S B 1102 - 1358 Jmol OpenAstexViewer
5B2T B 1102 - 1358 Jmol OpenAstexViewer
5F9R B 1102 - 1358 Jmol OpenAstexViewer
5FQ5 B 1102 - 1358 Jmol OpenAstexViewer
5FW1 B 1102 - 1358 Jmol OpenAstexViewer
5FW2 B 1102 - 1358 Jmol OpenAstexViewer
5FW3 B 1102 - 1358 Jmol OpenAstexViewer
Cas9_REC 181 - 710 4UN3 B 181 - 710 Jmol OpenAstexViewer
4ZT9 A 181 - 710 Jmol OpenAstexViewer
5FW1 B 181 - 710 Jmol OpenAstexViewer
181 - 712 4CMP A 181 - 712 Jmol OpenAstexViewer
B 181 - 712 Jmol OpenAstexViewer
4CMQ A 181 - 712 Jmol OpenAstexViewer
B 181 - 712 Jmol OpenAstexViewer
4OO8 A 181 - 712 Jmol OpenAstexViewer
D 181 - 712 Jmol OpenAstexViewer
4UN4 B 181 - 712 Jmol OpenAstexViewer
4UN5 B 181 - 712 Jmol OpenAstexViewer
4ZT0 A 181 - 712 Jmol OpenAstexViewer
C 181 - 712 Jmol OpenAstexViewer
4ZT9 C 181 - 712 Jmol OpenAstexViewer
5B2T B 181 - 712 Jmol OpenAstexViewer
5F9R B 181 - 712 Jmol OpenAstexViewer
5FQ5 B 181 - 712 Jmol OpenAstexViewer
5FW2 B 181 - 712 Jmol OpenAstexViewer
5FW3 B 181 - 712 Jmol OpenAstexViewer
184 - 712 5B2R B 184 - 712 Jmol OpenAstexViewer
5B2S B 184 - 712 Jmol OpenAstexViewer
HNH_4 821 - 872 4CMP A 821 - 872 Jmol OpenAstexViewer
B 821 - 872 Jmol OpenAstexViewer
4CMQ A 821 - 872 Jmol OpenAstexViewer
B 821 - 872 Jmol OpenAstexViewer
4OO8 A 821 - 872 Jmol OpenAstexViewer
4UN3 B 821 - 872 Jmol OpenAstexViewer
4UN4 B 821 - 872 Jmol OpenAstexViewer
4UN5 B 821 - 872 Jmol OpenAstexViewer
4ZT0 A 821 - 872 Jmol OpenAstexViewer
C 821 - 872 Jmol OpenAstexViewer
4ZT9 A 821 - 872 Jmol OpenAstexViewer
5B2R B 821 - 872 Jmol OpenAstexViewer
5B2S B 821 - 872 Jmol OpenAstexViewer
5B2T B 821 - 872 Jmol OpenAstexViewer
5F9R B 821 - 872 Jmol OpenAstexViewer
5FQ5 B 821 - 872 Jmol OpenAstexViewer
5FW1 B 821 - 872 Jmol OpenAstexViewer
5FW2 B 821 - 872 Jmol OpenAstexViewer
5FW3 B 821 - 872 Jmol OpenAstexViewer
839 - 854 4ZT9 C 839 - 854 Jmol OpenAstexViewer