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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TM175_HUMAN (Q9BSA9)

Summary

This is the summary of UniProt entry TM175_HUMAN (Q9BSA9).

Description: Endosomal/lysosomal potassium channel TMEM175 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 504 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 27
Pfam TMEM175 35 124
transmembrane n/a 39 58
transmembrane n/a 78 99
transmembrane n/a 111 133
transmembrane n/a 139 164
transmembrane n/a 185 205
transmembrane n/a 211 230
Pfam TMEM175 260 356
transmembrane n/a 310 327
transmembrane n/a 339 359
transmembrane n/a 380 399
transmembrane n/a 419 441
transmembrane n/a 453 476
low_complexity n/a 460 481
disorder n/a 484 497

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BSA9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSQPRTPEQA LDTPGDCPPG RRDEDAGEGI QCSQRMLSFS DALLSIIATV
50
51
MILPVTHTEI SPEQQFDRSV QRLLATRIAV YLMTFLIVTV AWAAHTRLFQ
100
101
VVGKTDDTLA LLNLACMMTI TFLPYTFSLM VTFPDVPLGI FLFCVCVIAI
150
151
GVVQALIVGY AFHFPHLLSP QIQRSAHRAL YRRHVLGIVL QGPALCFAAA
200
201
IFSLFFVPLS YLLMVTVILL PYVSKVTGWC RDRLLGHREP SAHPVEVFSF
250
251
DLHEPLSKER VEAFSDGVYA IVATLLILDI CEDNVPDPKD VKERFSGSLV
300
301
AALSATGPRF LAYFGSFATV GLLWFAHHSL FLHVRKATRA MGLLNTLSLA
350
351
FVGGLPLAYQ QTSAFARQPR DELERVRVSC TIIFLASIFQ LAMWTTALLH
400
401
QAETLQPSVW FGGREHVLMF AKLALYPCAS LLAFASTCLL SRFSVGIFHL
450
451
MQIAVPCAFL LLRLLVGLAL ATLRVLRGLA RPEHPPPAPT GQDDPQSQLL
500
501
PAPC                                                  
504
 

Show the unformatted sequence.

Checksums:
CRC64:7FEE4C22CA248094
MD5:a3c8a89870e10d25dd505e7df7e2df25

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TMEM175 260 - 356 6W8N A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
6W8O A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
6W8P A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
6WC9 A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
6WCA A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
6WCB A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
6WCC A 260 - 356 Show 3D Structure View in InterPro
B 260 - 356 Show 3D Structure View in InterPro
35 - 124 6W8N A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
6W8O A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
6W8P A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
6WC9 A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
6WCA A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
6WCB A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
6WCC A 35 - 124 Show 3D Structure View in InterPro
B 35 - 124 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;