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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CSN4_HUMAN (Q9BT78)

Summary

This is the summary of UniProt entry CSN4_HUMAN (Q9BT78).

Description: COP9 signalosome complex subunit 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 406 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PCI 264 363
Pfam CSN4_RPN5_eIF3a 365 406
disorder n/a 399 401

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BT78. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAVRQDLA QLMNSSGSHK DLAGKYRQIL EKAIQLSGAE QLEALKAFVE
50
51
AMVNENVSLV ISRQLLTDFC THLPNLPDST AKEIYHFTLE KIQPRVISFE
100
101
EQVASIRQHL ASIYEKEEDW RNAAQVLVGI PLETGQKQYN VDYKLETYLK
150
151
IARLYLEDDD PVQAEAYINR ASLLQNESTN EQLQIHYKVC YARVLDYRRK
200
201
FIEAAQRYNE LSYKTIVHES ERLEALKHAL HCTILASAGQ QRSRMLATLF
250
251
KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
300
301
DRAVIEHNLL SASKLYNNIT FEELGALLEI PAAKAEKIAS QMITEGRMNG
350
351
FIDQIDGIVH FETREALPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAM
400
401
EAQMAQ                                                
406
 

Show the unformatted sequence.

Checksums:
CRC64:4EFF9079058EB609
MD5:169eefb4a2b1e54e47f33dad3a44ac49

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CSN4_RPN5_eIF3a 365 - 406 4D10 D 365 - 406 Jmol OpenAstexViewer
L 365 - 406 Jmol OpenAstexViewer
4D18 D 365 - 406 Jmol OpenAstexViewer
L 365 - 406 Jmol OpenAstexViewer
4WSN b 365 - 406 Jmol OpenAstexViewer
D 365 - 406 Jmol OpenAstexViewer
j 365 - 406 Jmol OpenAstexViewer
L 365 - 406 Jmol OpenAstexViewer
r 365 - 406 Jmol OpenAstexViewer
T 365 - 406 Jmol OpenAstexViewer
PCI 264 - 362 4D0P A 264 - 362 Jmol OpenAstexViewer
264 - 363 4D10 D 264 - 363 Jmol OpenAstexViewer
L 264 - 363 Jmol OpenAstexViewer
4D18 D 264 - 363 Jmol OpenAstexViewer
L 264 - 363 Jmol OpenAstexViewer
4WSN b 264 - 363 Jmol OpenAstexViewer
D 264 - 363 Jmol OpenAstexViewer
j 264 - 363 Jmol OpenAstexViewer
L 264 - 363 Jmol OpenAstexViewer
r 264 - 363 Jmol OpenAstexViewer
T 264 - 363 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.