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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MKNK1_HUMAN (Q9BUB5)

Summary

This is the summary of UniProt entry MKNK1_HUMAN (Q9BUB5).

Description: MAP kinase-interacting serine/threonine-protein kinase 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 465 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 3 38
low_complexity n/a 22 34
Pfam Pkinase 50 172
disorder n/a 184 205
Pfam Pkinase 203 374
disorder n/a 375 377
disorder n/a 379 389
disorder n/a 412 428
low_complexity n/a 415 427
disorder n/a 431 432
low_complexity n/a 442 455
disorder n/a 443 465

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BUB5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL
50
51
TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ
100
101
CQGNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV
150
151
VRDVAAALDF LHTKDKVSLC HLGWSAMAPS GLTAAPTSLG SSDPPTSASQ
200
201
VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK LNNSCTPITT
250
251
PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP
300
301
FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL
350
351
ISKLLVRDAK QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL
400
401
FAAEAIALNR QLSQHEENEL AEEPEALADG LCSMKLSPPC KSRLARRRAL
450
451
AQAGRGEDRS PPTAL                                      
465
 

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Checksums:
CRC64:CAE225C35DCB2B43
MD5:c9be1bd12301019f6ee750057c8bf2d3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 206 - 374 2HW6 A 165 - 333 Jmol OpenAstexViewer
B 165 - 333 Jmol OpenAstexViewer
5WVD A 165 - 333 Jmol OpenAstexViewer
B 165 - 333 Jmol OpenAstexViewer
50 - 164 2HW6 A 50 - 164 Jmol OpenAstexViewer
B 50 - 164 Jmol OpenAstexViewer
5WVD A 50 - 164 Jmol OpenAstexViewer
B 50 - 164 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.