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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: PAPOG_HUMAN (Q9BWT3)

Summary

This is the summary of UniProt entry PAPOG_HUMAN (Q9BWT3).

Description: Poly(A) polymerase gamma EC=2.7.7.19
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 736 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 4 7
Pfam PAP_central 20 363
low_complexity n/a 60 71
Pfam NTP_transf_2 81 174
low_complexity n/a 177 192
transmembrane n/a 234 253
Pfam PAP_RNA-bind 365 431
disorder n/a 420 424
Pfam PAP_RNA-bind 421 506
disorder n/a 478 480
disorder n/a 506 507
disorder n/a 509 518
low_complexity n/a 520 535
disorder n/a 525 575
disorder n/a 580 583
disorder n/a 585 591
disorder n/a 597 603
disorder n/a 605 659
disorder n/a 662 665
disorder n/a 667 729

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BWT3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKEMSANTVL DSQRQQKHYG ITSPISLASP KEIDHIYTQK LIDAMKPFGV
50
51
FEDEEELNHR LVVLGKLNNL VKEWISDVSE SKNLPPSVVA TVGGKIFTFG
100
101
SYRLGVHTKG ADIDALCVAP RHVERSDFFQ SFFEKLKHQD GIRNLRAVED
150
151
AFVPVIKFEF DGIEIDLVFA RLAIQTISDN LDLRDDSRLR SLDIRCIRSL
200
201
NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML GFLGGVSWAM
250
251
LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD
300
301
PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI
350
351
LQGKSDWSKL LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL
400
401
VGNLERNEFI TLAHVNPQSF PGNKEHHKDN NYVSMWFLGI IFRRVENAES
450
451
VNIDLTYDIQ SFTDTVYRQA NNINMLKEGM KIEATHVKKK QLHHYLPAEI
500
501
LQKKKKQSLS DVNRSSGGLQ SKRLSLDSSC LDSSRDTDNG TPFNSPASKS
550
551
DSPSVGETER NSAEPAAVIV EKPLSVPPAQ GLSIPVIGAK VDSTVKTVSP
600
601
PTVCTIPTVV GRNVIPRITT PHNPAQGQPH LNGMSNITKT VTPKRSHSPS
650
651
IDGTPKRLKD VEKFIRLEST FKDPRTAEER KRKSVDAIGG ESMPIPTIDT
700
701
SRKKRLPSKE LPDSSSPVPA NNIRVIKNSI RLTLNR               
736
 

Show the unformatted sequence.

Checksums:
CRC64:B0F6F217AA36E552
MD5:bc44f437c1a3af309966a30a8aa16115

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NTP_transf_2 81 - 174 4LT6 A 81 - 174 Jmol OpenAstexViewer
B 81 - 174 Jmol OpenAstexViewer
PAP_central 20 - 363 4LT6 A 20 - 363 Jmol OpenAstexViewer
B 20 - 363 Jmol OpenAstexViewer
PAP_RNA-bind 365 - 431 4LT6 A 365 - 431 Jmol OpenAstexViewer
B 365 - 431 Jmol OpenAstexViewer
421 - 497 4LT6 B 421 - 497 Jmol OpenAstexViewer
421 - 501 4LT6 A 421 - 501 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.