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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IFIH1_HUMAN (Q9BYX4)

Summary

This is the summary of UniProt entry IFIH1_HUMAN (Q9BYX4).

Description: Interferon-induced helicase C domain-containing protein 1 EC=3.6.4.13
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1025 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam CARD_2 7 99
disorder n/a 94 95
low_complexity n/a 114 124
Pfam CARD 115 200
low_complexity n/a 124 136
disorder n/a 149 152
disorder n/a 154 158
disorder n/a 193 257
low_complexity n/a 243 258
disorder n/a 266 304
low_complexity n/a 276 291
Pfam ResIII 305 493
disorder n/a 307 313
low_complexity n/a 357 368
low_complexity n/a 416 427
low_complexity n/a 464 475
Pfam RIG-I_C 522 692
disorder n/a 584 587
disorder n/a 640 642
low_complexity n/a 641 672
disorder n/a 648 665
Pfam Helicase_C 699 826
disorder n/a 702 703
disorder n/a 707 708
disorder n/a 760 763
Pfam RIG-I_C-RD 903 1018

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9BYX4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSNGYSTDEN FRYLISCFRA RVKMYIQVEP VLDYLTFLPA EVKEQIQRTV
50
51
ATSGNMQAVE LLLSTLEKGV WHLGWTREFV EALRRTGSPL AARYMNPELT
100
101
DLPSPSFENA HDEYLQLLNL LQPTLVDKLL VRDVLDKCME EELLTIEDRN
150
151
RIAAAENNGN ESGVRELLKR IVQKENWFSA FLNVLRQTGN NELVQELTGS
200
201
DCSESNAEIE NLSQVDGPQV EEQLLSTTVQ PNLEKEVWGM ENNSSESSFA
250
251
DSSVVSESDT SLAEGSVSCL DESLGHNSNM GSDSGTMGSD SDEENVAARA
300
301
SPEPELQLRP YQMEVAQPAL EGKNIIICLP TGSGKTRVAV YIAKDHLDKK
350
351
KKASEPGKVI VLVNKVLLVE QLFRKEFQPF LKKWYRVIGL SGDTQLKISF
400
401
PEVVKSCDII ISTAQILENS LLNLENGEDA GVQLSDFSLI IIDECHHTNK
450
451
EAVYNNIMRH YLMQKLKNNR LKKENKPVIP LPQILGLTAS PGVGGATKQA
500
501
KAEEHILKLC ANLDAFTIKT VKENLDQLKN QIQEPCKKFA IADATREDPF
550
551
KEKLLEIMTR IQTYCQMSPM SDFGTQPYEQ WAIQMEKKAA KEGNRKERVC
600
601
AEHLRKYNEA LQINDTIRMI DAYTHLETFY NEEKDKKFAV IEDDSDEGGD
650
651
DEYCDGDEDE DDLKKPLKLD ETDRFLMTLF FENNKMLKRL AENPEYENEK
700
701
LTKLRNTIME QYTRTEESAR GIIFTKTRQS AYALSQWITE NEKFAEVGVK
750
751
AHHLIGAGHS SEFKPMTQNE QKEVISKFRT GKINLLIATT VAEEGLDIKE
800
801
CNIVIRYGLV TNEIAMVQAR GRARADESTY VLVAHSGSGV IEHETVNDFR
850
851
EKMMYKAIHC VQNMKPEEYA HKILELQMQS IMEKKMKTKR NIAKHYKNNP
900
901
SLITFLCKNC SVLACSGEDI HVIEKMHHVN MTPEFKELYI VRENKALQKK
950
951
CADYQINGEI ICKCGQAWGT MMVHKGLDLP CLKIRNFVVV FKNNSTKKQY
1000
1001
KKWVELPITF PNLDYSECCL FSDED                           
1025
 

Show the unformatted sequence.

Checksums:
CRC64:789CFB4824B92DC9
MD5:ff4697e04a17dd3588d00e847bd24c84

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Helicase_C 699 - 826 4GL2 A 699 - 826 Jmol OpenAstexViewer
B 699 - 826 Jmol OpenAstexViewer
ResIII 305 - 490 3B6E A 305 - 490 Jmol OpenAstexViewer
306 - 493 4GL2 A 306 - 493 Jmol OpenAstexViewer
B 306 - 493 Jmol OpenAstexViewer
RIG-I_C 522 - 692 4GL2 A 522 - 692 Jmol OpenAstexViewer
B 522 - 692 Jmol OpenAstexViewer
RIG-I_C-RD 903 - 1013 4GL2 A 903 - 1013 Jmol OpenAstexViewer
B 903 - 1013 Jmol OpenAstexViewer
903 - 1017 3GA3 A 903 - 1017 Jmol OpenAstexViewer
903 - 1018 2RQB A 903 - 1018 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.