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20  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FTO_HUMAN (Q9C0B1)

Summary

This is the summary of UniProt entry FTO_HUMAN (Q9C0B1).

Description: Alpha-ketoglutarate-dependent dioxygenase FTO {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 505 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 8
low_complexity n/a 7 24
Pfam FTO_NTD 36 325
low_complexity n/a 153 165
disorder n/a 253 264
Pfam FTO_CTD 329 498
low_complexity n/a 344 354

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9C0B1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI
50
51
LREASSVSEE LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG
100
101
NPGCTYKYLN TRLFTVPWPV KGSNIKHTEA EIAAACETFL KLNDYLQIET
150
151
IQALEELAAK EKANEDAVPL CMSADFPRVG MGSSYNGQDE VDIKSRAAYN
200
201
VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS AVAVYSYSCE
250
251
GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD
300
301
LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD
350
351
NDDVSLKSFE PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM
400
401
AQLEALWKKM EGVTNAVLHE VKREGLPVEQ RNEILTAILA SLTARQNLRR
450
451
EWHARCQSRI ARTLPADQKP ECRPYWEKDD ASMPLPFDLT DIVSELRGQL
500
501
LEAKP                                                 
505
 

Show the unformatted sequence.

Checksums:
CRC64:3498A92C6E6D81B1
MD5:74d227c963bd6a43b42ce75a7d538728

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FTO_CTD 329 - 498 3LFM A 329 - 498 Show 3D Structure View in InterPro
4CXW A 329 - 498 Show 3D Structure View in InterPro
4CXX A 329 - 498 Show 3D Structure View in InterPro
4CXY A 329 - 498 Show 3D Structure View in InterPro
4IDZ A 329 - 498 Show 3D Structure View in InterPro
4IE0 A 329 - 498 Show 3D Structure View in InterPro
4IE4 A 329 - 498 Show 3D Structure View in InterPro
4IE5 A 329 - 498 Show 3D Structure View in InterPro
4IE6 A 329 - 498 Show 3D Structure View in InterPro
4IE7 A 329 - 498 Show 3D Structure View in InterPro
4QHO A 329 - 498 Show 3D Structure View in InterPro
4QKN A 329 - 498 Show 3D Structure View in InterPro
4ZS2 A 329 - 498 Show 3D Structure View in InterPro
4ZS3 A 329 - 498 Show 3D Structure View in InterPro
5DAB A 329 - 498 Show 3D Structure View in InterPro
5F8P A 329 - 498 Show 3D Structure View in InterPro
5ZMD A 329 - 498 Show 3D Structure View in InterPro
C 329 - 498 Show 3D Structure View in InterPro
E 329 - 498 Show 3D Structure View in InterPro
G 329 - 498 Show 3D Structure View in InterPro
6AEJ A 329 - 498 Show 3D Structure View in InterPro
6AK4 A 329 - 498 Show 3D Structure View in InterPro
6AKW A 329 - 498 Show 3D Structure View in InterPro
FTO_NTD 36 - 325 3LFM A 36 - 325 Show 3D Structure View in InterPro
4CXW A 36 - 325 Show 3D Structure View in InterPro
4CXX A 36 - 325 Show 3D Structure View in InterPro
4CXY A 36 - 325 Show 3D Structure View in InterPro
4IDZ A 36 - 325 Show 3D Structure View in InterPro
4IE0 A 36 - 325 Show 3D Structure View in InterPro
4IE4 A 36 - 325 Show 3D Structure View in InterPro
4IE5 A 36 - 325 Show 3D Structure View in InterPro
4IE6 A 36 - 325 Show 3D Structure View in InterPro
4IE7 A 36 - 325 Show 3D Structure View in InterPro
4QHO A 36 - 325 Show 3D Structure View in InterPro
4QKN A 36 - 325 Show 3D Structure View in InterPro
4ZS2 A 36 - 325 Show 3D Structure View in InterPro
4ZS3 A 36 - 325 Show 3D Structure View in InterPro
5DAB A 36 - 325 Show 3D Structure View in InterPro
5F8P A 36 - 325 Show 3D Structure View in InterPro
6AEJ A 36 - 325 Show 3D Structure View in InterPro
6AK4 A 36 - 325 Show 3D Structure View in InterPro
6AKW A 36 - 325 Show 3D Structure View in InterPro
37 - 325 5ZMD A 37 - 325 Show 3D Structure View in InterPro
C 37 - 325 Show 3D Structure View in InterPro
E 37 - 325 Show 3D Structure View in InterPro
G 37 - 325 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;