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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KLC2_HUMAN (Q9H0B6)

Summary

This is the summary of UniProt entry KLC2_HUMAN (Q9H0B6).

Description: Kinesin light chain 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 622 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 42 46
coiled_coil n/a 85 140
disorder n/a 113 115
disorder n/a 120 127
disorder n/a 141 192
Pfam TPR_12 196 272
disorder n/a 226 234
Pfam TPR_12 261 314
low_complexity n/a 279 290
Pfam TPR_12 280 356
Pfam TPR_12 322 397
disorder n/a 406 429
low_complexity n/a 415 427
disorder n/a 452 456
disorder n/a 469 622
low_complexity n/a 496 509
low_complexity n/a 535 549
low_complexity n/a 596 619

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H0B6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMMVFPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLVAPEAGEA
50
51
EPGSQERCIL LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR
100
101
RLVQENQWLR EELAGTQQKL QRSEQAVAQL EEEKQHLLFM SQIRKLDEDA
150
151
SPNEEKGDVP KDTLDDLFPN EDEQSPAPSP GGGDVSGQHG GYEIPARLRT
200
201
LHNLVIQYAS QGRYEVAVPL CKQALEDLEK TSGHDHPDVA TMLNILALVY
250
251
RDQNKYKEAA HLLNDALAIR EKTLGKDHPA VAATLNNLAV LYGKRGKYKE
300
301
AEPLCKRALE IREKVLGKFH PDVAKQLSNL ALLCQNQGKA EEVEYYYRRA
350
351
LEIYATRLGP DDPNVAKTKN NLASCYLKQG KYQDAETLYK EILTRAHEKE
400
401
FGSVNGDNKP IWMHAEEREE SKDKRRDSAP YGEYGSWYKA CKVDSPTVNT
450
451
TLRSLGALYR RQGKLEAAHT LEDCASRNRK QGLDPASQTK VVELLKDGSG
500
501
RRGDRRSSRD MAGGAGPRSE SDLEDVGPTA EWNGDGSGSL RRSGSFGKLR
550
551
DALRRSSEML VKKLQGGTPQ EPPNPRMKRA SSLNFLNKSV EEPTQPGGTG
600
601
LSDSRTLSSS SMDLSRRSSL VG                              
622
 

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Checksums:
CRC64:5B57ABE4DF6E396E
MD5:07c229da3f8dcbf6af2bee90de23807d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TPR_12 217 - 272 3CEQ A 217 - 272 Jmol OpenAstexViewer
B 217 - 272 Jmol OpenAstexViewer
3EDT B 217 - 272 Jmol OpenAstexViewer
D 217 - 272 Jmol OpenAstexViewer
F 217 - 272 Jmol OpenAstexViewer
H 217 - 272 Jmol OpenAstexViewer
261 - 314 3CEQ A 261 - 314 Jmol OpenAstexViewer
B 261 - 314 Jmol OpenAstexViewer
3EDT B 261 - 314 Jmol OpenAstexViewer
D 261 - 314 Jmol OpenAstexViewer
F 261 - 314 Jmol OpenAstexViewer
H 261 - 314 Jmol OpenAstexViewer
280 - 356 3CEQ A 280 - 356 Jmol OpenAstexViewer
B 280 - 356 Jmol OpenAstexViewer
3EDT B 280 - 356 Jmol OpenAstexViewer
D 280 - 356 Jmol OpenAstexViewer
F 280 - 356 Jmol OpenAstexViewer
H 280 - 356 Jmol OpenAstexViewer
322 - 397 3CEQ A 322 - 397 Jmol OpenAstexViewer
B 322 - 397 Jmol OpenAstexViewer
3EDT B 322 - 397 Jmol OpenAstexViewer
D 322 - 397 Jmol OpenAstexViewer
F 322 - 397 Jmol OpenAstexViewer
H 322 - 397 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.