Summary
This is the summary of UniProt entry KLC2_HUMAN (Q9H0B6).
Description: | Kinesin light chain 2 |
Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
Length: | 622 amino acids |
Reference Proteome: |
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Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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Source | Domain | Start | End |
---|---|---|---|
disorder | n/a | 42 | 46 |
coiled_coil | n/a | 85 | 140 |
disorder | n/a | 113 | 115 |
disorder | n/a | 120 | 127 |
disorder | n/a | 141 | 192 |
Pfam | TPR_12 | 196 | 272 |
disorder | n/a | 226 | 234 |
Pfam | TPR_12 | 261 | 314 |
low_complexity | n/a | 279 | 290 |
Pfam | TPR_12 | 280 | 356 |
Pfam | TPR_12 | 322 | 397 |
disorder | n/a | 406 | 429 |
low_complexity | n/a | 415 | 427 |
disorder | n/a | 452 | 456 |
disorder | n/a | 469 | 622 |
low_complexity | n/a | 496 | 509 |
low_complexity | n/a | 535 | 549 |
low_complexity | n/a | 596 | 619 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H0B6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
Sequence: | 1
MAMMVFPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLVAPEAGEA
50 51
EPGSQERCIL LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR
100 101
RLVQENQWLR EELAGTQQKL QRSEQAVAQL EEEKQHLLFM SQIRKLDEDA
150 151
SPNEEKGDVP KDTLDDLFPN EDEQSPAPSP GGGDVSGQHG GYEIPARLRT
200 201
LHNLVIQYAS QGRYEVAVPL CKQALEDLEK TSGHDHPDVA TMLNILALVY
250 251
RDQNKYKEAA HLLNDALAIR EKTLGKDHPA VAATLNNLAV LYGKRGKYKE
300 301
AEPLCKRALE IREKVLGKFH PDVAKQLSNL ALLCQNQGKA EEVEYYYRRA
350 351
LEIYATRLGP DDPNVAKTKN NLASCYLKQG KYQDAETLYK EILTRAHEKE
400 401
FGSVNGDNKP IWMHAEEREE SKDKRRDSAP YGEYGSWYKA CKVDSPTVNT
450 451
TLRSLGALYR RQGKLEAAHT LEDCASRNRK QGLDPASQTK VVELLKDGSG
500 501
RRGDRRSSRD MAGGAGPRSE SDLEDVGPTA EWNGDGSGSL RRSGSFGKLR
550 551
DALRRSSEML VKKLQGGTPQ EPPNPRMKRA SSLNFLNKSV EEPTQPGGTG
600 601
LSDSRTLSSS SMDLSRRSSL VG
622
Show the unformatted sequence. |
Checksums: |
CRC64:5B57ABE4DF6E396E
MD5:07c229da3f8dcbf6af2bee90de23807d
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
---|---|---|---|---|---|
TPR_12 | 217 - 272 | 3CEQ | A | 217 - 272 | Jmol OpenAstexViewer |
B | 217 - 272 | Jmol OpenAstexViewer | |||
3EDT | B | 217 - 272 | Jmol OpenAstexViewer | ||
D | 217 - 272 | Jmol OpenAstexViewer | |||
F | 217 - 272 | Jmol OpenAstexViewer | |||
H | 217 - 272 | Jmol OpenAstexViewer | |||
261 - 314 | 3CEQ | A | 261 - 314 | Jmol OpenAstexViewer | |
B | 261 - 314 | Jmol OpenAstexViewer | |||
3EDT | B | 261 - 314 | Jmol OpenAstexViewer | ||
D | 261 - 314 | Jmol OpenAstexViewer | |||
F | 261 - 314 | Jmol OpenAstexViewer | |||
H | 261 - 314 | Jmol OpenAstexViewer | |||
280 - 356 | 3CEQ | A | 280 - 356 | Jmol OpenAstexViewer | |
B | 280 - 356 | Jmol OpenAstexViewer | |||
3EDT | B | 280 - 356 | Jmol OpenAstexViewer | ||
D | 280 - 356 | Jmol OpenAstexViewer | |||
F | 280 - 356 | Jmol OpenAstexViewer | |||
H | 280 - 356 | Jmol OpenAstexViewer | |||
322 - 397 | 3CEQ | A | 322 - 397 | Jmol OpenAstexViewer | |
B | 322 - 397 | Jmol OpenAstexViewer | |||
3EDT | B | 322 - 397 | Jmol OpenAstexViewer | ||
D | 322 - 397 | Jmol OpenAstexViewer | |||
F | 322 - 397 | Jmol OpenAstexViewer | |||
H | 322 - 397 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.