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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RGAP1_HUMAN (Q9H0H5)

Summary

This is the summary of UniProt entry RGAP1_HUMAN (Q9H0H5).

Description: Rac GTPase-activating protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 632 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
coiled_coil n/a 58 106
disorder n/a 126 134
disorder n/a 136 144
disorder n/a 183 211
disorder n/a 213 224
disorder n/a 226 230
disorder n/a 232 236
disorder n/a 247 250
disorder n/a 252 283
disorder n/a 286 288
Pfam C1_1 287 338
Pfam RhoGAP 363 509
disorder n/a 515 520
disorder n/a 555 558
disorder n/a 570 575
disorder n/a 581 616
low_complexity n/a 590 603

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H0H5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE
50
51
LGKYKDLLMK AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI
100
101
QLIREMLMCD TSGSIQLSEE QKSALAFLNR GQPSSSNAGN KRLSTIDESG
150
151
SILSDISFDK TDESLDWDSS LVKTFKLKKR EKRRSTSRQF VDGPPGPVKK
200
201
TRSIGSAVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP YWTRSRRKTG
250
251
TLQPWNSDST LNSRQLEPRT ETDSVGTPQS NGGMRLHDFV SKTVIKPESC
300
301
VPCGKRIKFG KLSLKCRDCR VVSHPECRDR CPLPCIPTLI GTPVKIGEGM
350
351
LADFVSQTSP MIPSIVVHCV NEIEQRGLTE TGLYRISGCD RTVKELKEKF
400
401
LRVKTVPLLS KVDDIHAICS LLKDFLRNLK EPLLTFRLNR AFMEAAEITD
450
451
EDNSIAAMYQ AVGELPQANR DTLAFLMIHL QRVAQSPHTK MDVANLAKVF
500
501
GPTIVAHAVP NPDPVTMLQD IKRQPKVVER LLSLPLEYWS QFMMVEQENI
550
551
DPLHVIENSN AFSTPQTPDI KVSLLGPVTT PEHQLLKTPS SSSLSQRVRS
600
601
TLTKNTPRFG SKSKSATNLG RQGNFFASPM LK                   
632
 

Show the unformatted sequence.

Checksums:
CRC64:032B7DF9CEA8F39D
MD5:1f931fcb446dbb8ff0b3d0b5e8d4858c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1_1 287 - 338 4B6D A 287 - 338 Show 3D Structure View in InterPro
B 287 - 338 Show 3D Structure View in InterPro
C 287 - 338 Show 3D Structure View in InterPro
D 287 - 338 Show 3D Structure View in InterPro
E 287 - 338 Show 3D Structure View in InterPro
F 287 - 338 Show 3D Structure View in InterPro
RhoGAP 363 - 509 2OVJ A 363 - 509 Show 3D Structure View in InterPro
3W6R A 363 - 509 Show 3D Structure View in InterPro
3WPQ A 363 - 509 Show 3D Structure View in InterPro
B 363 - 509 Show 3D Structure View in InterPro
3WPS A 363 - 509 Show 3D Structure View in InterPro
B 363 - 509 Show 3D Structure View in InterPro
5C2J A 363 - 509 Show 3D Structure View in InterPro
5C2K A 225 - 371 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;