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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: ABCG5_HUMAN (Q9H222)

Summary

This is the summary of UniProt entry ABCG5_HUMAN (Q9H222).

Description: ATP-binding cassette sub-family G member 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 651 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 3
disorder n/a 11 13
disorder n/a 15 31
Pfam ABC_tran 69 221
Pfam ABC2_membrane 366 580
low_complexity n/a 367 380
transmembrane n/a 384 405
low_complexity n/a 397 407
transmembrane n/a 426 445
transmembrane n/a 465 490
transmembrane n/a 502 523
transmembrane n/a 529 549
transmembrane n/a 625 644

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H222. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGDLSSLTPG GSMGLQVNRG SQSSLEGAPA TAPEPHSLGI LHASYSVSHR
50
51
VRPWWDITSC RQQWTRQILK DVSLYVESGQ IMCILGSSGS GKTTLLDAMS
100
101
GRLGRAGTFL GEVYVNGRAL RREQFQDCFS YVLQSDTLLS SLTVRETLHY
150
151
TALLAIRRGN PGSFQKKVEA VMAELSLSHV ADRLIGNYSL GGISTGERRR
200
201
VSIAAQLLQD PKVMLFDEPT TGLDCMTANQ IVVLLVELAR RNRIVVLTIH
250
251
QPRSELFQLF DKIAILSFGE LIFCGTPAEM LDFFNDCGYP CPEHSNPFDF
300
301
YMDLTSVDTQ SKEREIETSK RVQMIESAYK KSAICHKTLK NIERMKHLKT
350
351
LPMVPFKTKD SPGVFSKLGV LLRRVTRNLV RNKLAVITRL LQNLIMGLFL
400
401
LFFVLRVRSN VLKGAIQDRV GLLYQFVGAT PYTGMLNAVN LFPVLRAVSD
450
451
QESQDGLYQK WQMMLAYALH VLPFSVVATM IFSSVCYWTL GLHPEVARFG
500
501
YFSAALLAPH LIGEFLTLVL LGIVQNPNIV NSVVALLSIA GVLVGSGFLR
550
551
NIQEMPIPFK IISYFTFQKY CSEILVVNEF YGLNFTCGSS NVSVTTNPMC
600
601
AFTQGIQFIE KTCPGATSRF TMNFLILYSF IPALVILGIV VFKIRDHLIS
650
651
R                                                     
651
 

Show the unformatted sequence.

Checksums:
CRC64:950BABFCBB6A1536
MD5:1ab5418aa2738f2e9207f5d70f92d169

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ABC2_membrane 366 - 580 5DO7 A 366 - 580 Jmol OpenAstexViewer
C 366 - 580 Jmol OpenAstexViewer
ABC_tran 69 - 221 5DO7 A 69 - 221 Jmol OpenAstexViewer
C 69 - 221 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.