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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ADNP_HUMAN (Q9H2P0)

Summary

This is the summary of UniProt entry ADNP_HUMAN (Q9H2P0).

Description: Activity-dependent neuroprotector homeobox protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1102 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam ADNP_N 1 754
low_complexity n/a 130 141
disorder n/a 139 140
disorder n/a 145 146
disorder n/a 151 152
disorder n/a 208 211
disorder n/a 267 268
disorder n/a 271 277
disorder n/a 280 292
disorder n/a 294 295
disorder n/a 301 313
disorder n/a 318 322
disorder n/a 349 358
disorder n/a 360 395
low_complexity n/a 393 407
low_complexity n/a 400 418
disorder n/a 403 409
disorder n/a 413 420
disorder n/a 422 439
low_complexity n/a 424 441
disorder n/a 532 536
disorder n/a 547 550
disorder n/a 580 611
low_complexity n/a 584 597
disorder n/a 646 648
disorder n/a 691 712
low_complexity n/a 725 740
low_complexity n/a 733 740
disorder n/a 737 740
low_complexity n/a 738 749
disorder n/a 752 758
Pfam Homeodomain 765 812
disorder n/a 851 1030
low_complexity n/a 871 889
low_complexity n/a 953 964
low_complexity n/a 1006 1017
disorder n/a 1039 1102

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H2P0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFQLPVNNLG SLRKARKTVK KILSDIGLEY CKEHIEDFKQ FEPNDFYLKN
50
51
TTWEDVGLWD PSLTKNQDYR TKPFCCSACP FSSKFFSAYK SHFRNVHSED
100
101
FENRILLNCP YCTFNADKKT LETHIKIFHA PNASAPSSSL STFKDKNKND
150
151
GLKPKQADSV EQAVYYCKKC TYRDPLYEIV RKHIYREHFQ HVAAPYIAKA
200
201
GEKSLNGAVP LGSNAREESS IHCKRCLFMP KSYEALVQHV IEDHERIGYQ
250
251
VTAMIGHTNV VVPRSKPLML IAPKPQDKKS MGLPPRIGSL ASGNVRSLPS
300
301
QQMVNRLSIP KPNLNSTGVN MMSSVHLQQN NYGVKSVGQG YSVGQSMRLG
350
351
LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GSEQRSQAPA RYSLQSANAS
400
401
SLSSGQLKSP SLSQSQASRV LGQSSSKPAA AATGPPPGNT SSTQKWKICT
450
451
ICNELFPENV YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLPT
500
501
DTLLNHMLIH GLSCPYCRST FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF
550
551
DLTLQQGSHT NIHLLVTTYN LRDAPAESVA YHAQNNPPVP PKPQPKVQEK
600
601
ADIPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA HHLRERHQVI
650
651
QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT
700
701
NAPSRLNQSP SLAPVKRTYE QMEFPLLKKR KLDDDSDSPS FFEEKPEEPV
750
751
VLALDPKGHE DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI
800
801
ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF DAEWLFENHD
850
851
EKDSRVNASK TADKKLNLGK EDDSSSDSFE NLEEESNESG SPFDPVFEVE
900
901
PKISNDNPEE HVLKVIPEDA SESEEKLDQK EDGSKYETIH LTEEPTKLMH
950
951
NASDSEVDQD DVVEWKDGAS PSESGPGSQQ VSDFEDNTCE MKPGTWSDES
1000
1001
SQSEDARSSK PAAKKKATMQ GDREQLKWKN SSYGKVEGFW SKDQSQWKNA
1050
1051
SENDERLSNP QIEWQNSTID SEDGEQFDNM TDGVAEPMHG SLAGVKLSSQ
1100
1101
QA                                                    
1102
 

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Checksums:
CRC64:4132E3EF814AF43B
MD5:5636fdef92216e5ec12ad878c002695e

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;