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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NKX24_HUMAN (Q9H2Z4)

Summary

This is the summary of UniProt entry NKX24_HUMAN (Q9H2Z4).

Description: Homeobox protein Nkx-2.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 354 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 4
disorder n/a 11 12
disorder n/a 14 15
low_complexity n/a 33 55
disorder n/a 42 51
disorder n/a 53 67
low_complexity n/a 76 91
disorder n/a 180 183
low_complexity n/a 181 187
Pfam Homeodomain 190 246
disorder n/a 208 210
disorder n/a 212 216
disorder n/a 219 225
disorder n/a 239 241
coiled_coil n/a 239 259
low_complexity n/a 245 258
disorder n/a 246 337
low_complexity n/a 254 263
low_complexity n/a 264 281
low_complexity n/a 292 322
low_complexity n/a 315 341

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H2Z4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLSPKHTTP FSVSDILSPI EETYKKFSGA MDGAPPGLGA PLGAAAAYRA
50
51
PPPGPSSQAA TVAGMQPSHA MAGHNAAAAA AAAAAAAAAA ATYHMPPGVS
100
101
QFPHGAMGSY CNGGLGNMGE LPAYTDGMRG GAATGWYGAN PDPRYSSISR
150
151
FMGPSAGVNV AGMGSLTGIA DAAKSLGPLH AAAAAAAPRR KRRVLFSQAQ
200
201
VYELERRFKQ QKYLSAPERE HLASMIHLTP TQVKIWFQNH RYKMKRQAKD
250
251
KAAQQLQQEG GLGPPPPPPP SPRRVAVPVL VKDGKPCQNG ASTPTPGQAG
300
301
PQPPAPTPAP ELEELSPSPP ALHGPGGGLA ALDAAAGEYS GGVLGANLLY
350
351
GRTW                                                  
354
 

Show the unformatted sequence.

Checksums:
CRC64:A2A8963F9A2C5356
MD5:45c13abf3a73d5b209dc612bcd1116ef

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;