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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: P63_HUMAN (Q9H3D4)

Summary

This is the summary of UniProt entry P63_HUMAN (Q9H3D4).

Description: Tumor protein 63
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 680 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 73 74
disorder n/a 77 83
disorder n/a 87 91
disorder n/a 122 180
Pfam P53 167 359
disorder n/a 227 228
disorder n/a 251 253
disorder n/a 260 261
disorder n/a 286 287
disorder n/a 351 352
disorder n/a 355 391
Pfam P53_tetramer 391 431
disorder n/a 396 399
disorder n/a 401 402
disorder n/a 428 540
low_complexity n/a 437 450
Pfam SAM_2 541 605
disorder n/a 613 614
disorder n/a 621 630
low_complexity n/a 621 631
disorder n/a 669 680

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H3D4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL
50
51
SPEVFQHIWD FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD
100
101
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA
150
151
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK
200
201
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS
250
251
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT
300
301
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR
350
351
DRKADEDSIR KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL
400
401
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ
450
451
TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTIPDGMG
500
501
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV
550
551
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG
600
601
ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI
650
651
SFPPRDEWND FNFDMDARRN KQQRIKEEGE                      
680
 

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Checksums:
CRC64:F66ECD45E87D9799
MD5:7c3a66b8403223e802e1a24563190ea7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
P53 167 - 358 3US1 A 128 - 319 Show 3D Structure View in InterPro
3US2 A 128 - 319 Show 3D Structure View in InterPro
C 128 - 319 Show 3D Structure View in InterPro
G 128 - 319 Show 3D Structure View in InterPro
I 128 - 319 Show 3D Structure View in InterPro
167 - 359 2RMN A 128 - 320 Show 3D Structure View in InterPro
3QYM A 128 - 320 Show 3D Structure View in InterPro
B 128 - 320 Show 3D Structure View in InterPro
C 128 - 320 Show 3D Structure View in InterPro
D 128 - 320 Show 3D Structure View in InterPro
E 128 - 320 Show 3D Structure View in InterPro
F 128 - 320 Show 3D Structure View in InterPro
G 128 - 320 Show 3D Structure View in InterPro
H 128 - 320 Show 3D Structure View in InterPro
3QYN A 128 - 320 Show 3D Structure View in InterPro
B 128 - 320 Show 3D Structure View in InterPro
C 128 - 320 Show 3D Structure View in InterPro
D 128 - 320 Show 3D Structure View in InterPro
3US0 A 128 - 320 Show 3D Structure View in InterPro
B 128 - 320 Show 3D Structure View in InterPro
C 128 - 320 Show 3D Structure View in InterPro
D 128 - 320 Show 3D Structure View in InterPro
170 - 359 3US1 D 131 - 320 Show 3D Structure View in InterPro
3US2 B 131 - 320 Show 3D Structure View in InterPro
D 131 - 320 Show 3D Structure View in InterPro
H 131 - 320 Show 3D Structure View in InterPro
J 131 - 320 Show 3D Structure View in InterPro
P53_tetramer 397 - 431 2NB1 A 2 - 36 Show 3D Structure View in InterPro
C 1002 - 1036 Show 3D Structure View in InterPro
4A9Z A 358 - 392 Show 3D Structure View in InterPro
B 358 - 392 Show 3D Structure View in InterPro
C 358 - 392 Show 3D Structure View in InterPro
D 358 - 392 Show 3D Structure View in InterPro
398 - 427 3ZY0 A 359 - 388 Show 3D Structure View in InterPro
398 - 431 3ZY1 A 359 - 392 Show 3D Structure View in InterPro
400 - 425 3ZY0 D 361 - 386 Show 3D Structure View in InterPro
400 - 427 3ZY0 B 361 - 388 Show 3D Structure View in InterPro
C 361 - 388 Show 3D Structure View in InterPro
SAM_2 543 - 605 2Y9T A 543 - 605 Show 3D Structure View in InterPro
544 - 605 1RG6 A 5 - 66 Show 3D Structure View in InterPro
545 - 605 2Y9U A 545 - 605 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;