Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TXNIP_HUMAN (Q9H3M7)

Summary

This is the summary of UniProt entry TXNIP_HUMAN (Q9H3M7).

Description: Thioredoxin-interacting protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 391 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Arrestin_N 10 152
Pfam Arrestin_C 174 300
low_complexity n/a 296 317
disorder n/a 305 308
disorder n/a 320 321
disorder n/a 335 339
disorder n/a 345 353
disorder n/a 383 385

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H3M7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG
50
51
VAKVLWMQGS QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK
100
101
FGFELPQGPL GTSFKGKYGC VDYWVKAFLD RPSQPTQETK KNFEVVDLVD
150
151
VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV SARIDRKGFC EGDEISIHAD
200
201
FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN HIISGTCASW
250
251
RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS
300
301
GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDVIPE DHRLESPTTP
350
351
LLDDMDGSQD SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q         
391
 

Show the unformatted sequence.

Checksums:
CRC64:B0FE2D35D0B0735A
MD5:b733996346594319bc075b17db8c6a6c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Arrestin_C 174 - 298 4LL1 A 174 - 298 Jmol OpenAstexViewer
4LL4 A 174 - 298 Jmol OpenAstexViewer
174 - 299 4LL1 C 174 - 299 Jmol OpenAstexViewer
4LL4 C 174 - 299 Jmol OpenAstexViewer
Arrestin_N 10 - 145 4LL4 A 10 - 145 Jmol OpenAstexViewer
10 - 146 4LL1 A 10 - 146 Jmol OpenAstexViewer
10 - 147 4LL1 C 10 - 147 Jmol OpenAstexViewer
10 - 148 4LL4 C 10 - 148 Jmol OpenAstexViewer
10 - 149 4GEI A 10 - 149 Jmol OpenAstexViewer
4GEJ A 10 - 149 Jmol OpenAstexViewer
B 10 - 149 Jmol OpenAstexViewer
C 10 - 149 Jmol OpenAstexViewer
D 10 - 149 Jmol OpenAstexViewer
E 10 - 149 Jmol OpenAstexViewer
F 10 - 149 Jmol OpenAstexViewer
G 10 - 149 Jmol OpenAstexViewer
H 10 - 149 Jmol OpenAstexViewer
I 10 - 149 Jmol OpenAstexViewer
J 10 - 149 Jmol OpenAstexViewer
10 - 152 4GFX A 10 - 152 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.