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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SOX17_HUMAN (Q9H6I2)

Summary

This is the summary of UniProt entry SOX17_HUMAN (Q9H6I2).

Description: Transcription factor SOX-17
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 414 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 24
disorder n/a 38 66
low_complexity n/a 45 63
Pfam HMG_box 68 136
disorder n/a 73 74
disorder n/a 79 81
disorder n/a 83 99
disorder n/a 119 126
disorder n/a 128 143
low_complexity n/a 135 149
disorder n/a 146 153
disorder n/a 159 164
disorder n/a 166 183
disorder n/a 185 241
low_complexity n/a 191 196
Pfam Sox17_18_mid 203 253
low_complexity n/a 230 239
disorder n/a 250 287
low_complexity n/a 259 268
disorder n/a 297 301
low_complexity n/a 297 309
disorder n/a 303 359
low_complexity n/a 311 336
disorder n/a 379 396
low_complexity n/a 393 405

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H6I2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSPDAGYAS DDQSQTQSAL PAVMAGLGPC PWAESLSPIG DMKVKGEAPA
50
51
NSGAPAGAAG RAKGESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK
100
101
MLGKSWKALT LAEKRPFVEE AERLRVQHMQ DHPNYKYRPR RRKQVKRLKR
150
151
VEGGFLHGLA EPQAAALGPE GGRVAMDGLG LQFPEQGFPA GPPLLPPHMG
200
201
GHYRDCQSLG APPLDGYPLP TPDTSPLDGV DPDPAFFAAP MPGDCPAAGT
250
251
YSYAQVSDYA GPPEPPAGPM HPRLGPEPAG PSIPGLLAPP SALHVYYGAM
300
301
GSPGAGGGRG FQMQPQHQHQ HQHQHHPPGP GQPSPPPEAL PCRDGTDPSQ
350
351
PAELLGEVDR TEFEQYLHFV CKPEMGLPYQ GHDSGVNLPD SHGAISSVVS
400
401
DASSAVYYCN YPDV                                       
414
 

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Checksums:
CRC64:C78D1F24BA00ECD1
MD5:9478553ca2ed56c4cadf5bed2f21c32f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HMG_box 68 - 136 2YUL A 8 - 76 Jmol OpenAstexViewer
70 - 134 4A3N A 70 - 134 Jmol OpenAstexViewer