Summary
This is the summary of UniProt entry YTDC2_HUMAN (Q9H6S0).
| Description: | 3'-5' RNA helicase YTHDC2 {ECO:0000305} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 1430 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 37 |
| low_complexity | n/a | 13 | 30 |
| Pfam | R3H | 45 | 104 |
| disorder | n/a | 62 | 65 |
| disorder | n/a | 67 | 73 |
| disorder | n/a | 96 | 107 |
| disorder | n/a | 110 | 119 |
| disorder | n/a | 130 | 132 |
| disorder | n/a | 141 | 142 |
| disorder | n/a | 150 | 151 |
| disorder | n/a | 155 | 162 |
| disorder | n/a | 164 | 177 |
| Pfam | DEAD | 196 | 355 |
| low_complexity | n/a | 196 | 214 |
| low_complexity | n/a | 248 | 267 |
| disorder | n/a | 395 | 402 |
| low_complexity | n/a | 397 | 412 |
| disorder | n/a | 408 | 410 |
| Pfam | Helicase_C | 607 | 744 |
| Pfam | HA2 | 809 | 928 |
| Pfam | OB_NTP_bind | 971 | 1067 |
| disorder | n/a | 1080 | 1098 |
| disorder | n/a | 1165 | 1289 |
| low_complexity | n/a | 1190 | 1201 |
| low_complexity | n/a | 1247 | 1283 |
| Pfam | YTH | 1288 | 1362 |
| disorder | n/a | 1303 | 1312 |
| disorder | n/a | 1345 | 1348 |
| Pfam | YTH | 1351 | 1419 |
| disorder | n/a | 1356 | 1357 |
| disorder | n/a | 1429 | 1430 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H6S0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSRPSSVSPR QPAPGGGGGG GPSPCGPGGG GRAKGLKDIR IDEEVKIAVN
50 51
IALERFRYGD QREMEFPSSL TSTERAFIHR LSQSLGLVSK SKGKGANRYL
100 101
TVKKKDGSET AHAMMTCNLT HNTKHAVRSL IQRFPVTNKE RTELLPKTER
150 151
GNVFAVEAEN REMSKTSGRL NNGIPQIPVK RGESEFDSFR QSLPVFEKQE
200 201
EIVKIIKENK VVLIVGETGS GKTTQIPQFL LDDCFKNGIP CRIFCTQPRR
250 251
LAAIAVAERV AAERRERIGQ TIGYQIRLES RVSPKTLLTF CTNGVLLRTL
300 301
MAGDSTLSTV THVIVDEVHE RDRFSDFLLT KLRDLLQKHP TLKLILSSAA
350 351
LDVNLFIRYF GSCPVIYIQG RPFEVKEMFL EDILRTTGYT NKEMLKYKKE
400 401
KQQEEKQQTT LTEWYSAQEN SFKPESQRQR TVLNVTDEYD LLDDGGDAVF
450 451
SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK DIDAFAQVFH LILTENVSVD
500 501
YRHSETSATA LMVAAGRGFA SQVEQLISMG ANVHSKASNG WMALDWAKHF
550 551
GQTEIVDLLE SYSATLEFGN LDESSLVQTN GSDLSAEDRE LLKAYHHSFD
600 601
DEKVDLDLIM HLLYNICHSC DAGAVLIFLP GYDEIVGLRD RILFDDKRFA
650 651
DSTHRYQVFM LHSNMQTSDQ KKVLKNPPAG VRKIILSTNI AETSITVNDV
700 701
VFVIDSGKVK EKSFDALNFV TMLKMVWISK ASAIQRKGRA GRCRPGICFR
750 751
LFSRLRFQNM LEFQTPELLR MPLQELCLHT KLLAPVNCPI ADFLMKAPEP
800 801
PPALIVRNAV QMLKTIDAMD TWEDLTELGY HLADLPVEPH LGKMVLCAVV
850 851
LKCLDPILTI ACTLAYRDPF VLPTQASQKR AAMLCRKRFT AGAFSDHMAL
900 901
LRAFQAWQKA RSDGWERAFC EKNFLSQATM EIIIGMRTQL LGQLRASGFV
950 951
RARGGGDIRD VNTNSENWAV VKAALVAGMY PNLVHVDREN LVLTGPKEKK
1000 1001
VRFHPASVLS QPQYKKIPPA NGQAAAIKAL PTDWLIYDEM TRAHRIANIR
1050 1051
CCSAVTPVTI LVFCGPARLA SNALQEPSSF RVDGIPNDSS DSEMEDKTTA
1100 1101
NLAALKLDEW LHFTLEPEAA SLLLQLRQKW HSLFLRRMRA PSKPWSQVDE
1150 1151
ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNNSRK
1200 1201
SSADTEFSDE CTTAERVLMK SPSPALHPPQ KYKDRGILHP KRGTEDRSDQ
1250 1251
SSLKSTDSSS YPSPCASPSP PSSGKGSKSP SPRPNMPVRY FIMKSSNLRN
1300 1301
LEISQQKGIW STTPSNERKL NRAFWESSIV YLVFSVQGSG HFQGFSRMSS
1350 1351
EIGREKSQDW GSAGLGGVFK VEWIRKESLP FQFAHHLLNP WNDNKKVQIS
1400 1401
RDGQELEPLV GEQLLQLWER LPLGEKNTTD
1430
Show the unformatted sequence. |
| Checksums: |
CRC64:A0C3B45771A3DE16
MD5:3f36c8e82ae8f524e6beaa8dfc050f46
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| YTH | 1288 - 1362 | 2YU6 | A | 8 - 82 | Jmol OpenAstexViewer |
| 1351 - 1419 | 2YU6 | A | 71 - 139 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
