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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: YTDC2_HUMAN (Q9H6S0)

Summary

This is the summary of UniProt entry YTDC2_HUMAN (Q9H6S0).

Description: Probable ATP-dependent RNA helicase YTHDC2 EC=3.6.4.13
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1430 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 37
low_complexity n/a 13 30
Pfam R3H 45 104
disorder n/a 62 65
disorder n/a 67 73
disorder n/a 96 107
disorder n/a 110 119
disorder n/a 130 132
disorder n/a 141 142
disorder n/a 150 151
disorder n/a 155 162
disorder n/a 164 177
Pfam DEAD 196 355
low_complexity n/a 196 214
low_complexity n/a 248 267
disorder n/a 395 402
low_complexity n/a 397 412
disorder n/a 408 410
Pfam Helicase_C 607 744
Pfam HA2 809 929
Pfam OB_NTP_bind 971 1067
disorder n/a 1080 1098
disorder n/a 1165 1289
low_complexity n/a 1190 1201
low_complexity n/a 1247 1283
Pfam YTH 1288 1419
disorder n/a 1303 1312
disorder n/a 1345 1348
disorder n/a 1356 1357
disorder n/a 1429 1430

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9H6S0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRPSSVSPR QPAPGGGGGG GPSPCGPGGG GRAKGLKDIR IDEEVKIAVN
50
51
IALERFRYGD QREMEFPSSL TSTERAFIHR LSQSLGLVSK SKGKGANRYL
100
101
TVKKKDGSET AHAMMTCNLT HNTKHAVRSL IQRFPVTNKE RTELLPKTER
150
151
GNVFAVEAEN REMSKTSGRL NNGIPQIPVK RGESEFDSFR QSLPVFEKQE
200
201
EIVKIIKENK VVLIVGETGS GKTTQIPQFL LDDCFKNGIP CRIFCTQPRR
250
251
LAAIAVAERV AAERRERIGQ TIGYQIRLES RVSPKTLLTF CTNGVLLRTL
300
301
MAGDSTLSTV THVIVDEVHE RDRFSDFLLT KLRDLLQKHP TLKLILSSAA
350
351
LDVNLFIRYF GSCPVIYIQG RPFEVKEMFL EDILRTTGYT NKEMLKYKKE
400
401
KQQEEKQQTT LTEWYSAQEN SFKPESQRQR TVLNVTDEYD LLDDGGDAVF
450
451
SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK DIDAFAQVFH LILTENVSVD
500
501
YRHSETSATA LMVAAGRGFA SQVEQLISMG ANVHSKASNG WMALDWAKHF
550
551
GQTEIVDLLE SYSATLEFGN LDESSLVQTN GSDLSAEDRE LLKAYHHSFD
600
601
DEKVDLDLIM HLLYNICHSC DAGAVLIFLP GYDEIVGLRD RILFDDKRFA
650
651
DSTHRYQVFM LHSNMQTSDQ KKVLKNPPAG VRKIILSTNI AETSITVNDV
700
701
VFVIDSGKVK EKSFDALNFV TMLKMVWISK ASAIQRKGRA GRCRPGICFR
750
751
LFSRLRFQNM LEFQTPELLR MPLQELCLHT KLLAPVNCPI ADFLMKAPEP
800
801
PPALIVRNAV QMLKTIDAMD TWEDLTELGY HLADLPVEPH LGKMVLCAVV
850
851
LKCLDPILTI ACTLAYRDPF VLPTQASQKR AAMLCRKRFT AGAFSDHMAL
900
901
LRAFQAWQKA RSDGWERAFC EKNFLSQATM EIIIGMRTQL LGQLRASGFV
950
951
RARGGGDIRD VNTNSENWAV VKAALVAGMY PNLVHVDREN LVLTGPKEKK
1000
1001
VRFHPASVLS QPQYKKIPPA NGQAAAIKAL PTDWLIYDEM TRAHRIANIR
1050
1051
CCSAVTPVTI LVFCGPARLA SNALQEPSSF RVDGIPNDSS DSEMEDKTTA
1100
1101
NLAALKLDEW LHFTLEPEAA SLLLQLRQKW HSLFLRRMRA PSKPWSQVDE
1150
1151
ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNNSRK
1200
1201
SSADTEFSDE CTTAERVLMK SPSPALHPPQ KYKDRGILHP KRGTEDRSDQ
1250
1251
SSLKSTDSSS YPSPCASPSP PSSGKGSKSP SPRPNMPVRY FIMKSSNLRN
1300
1301
LEISQQKGIW STTPSNERKL NRAFWESSIV YLVFSVQGSG HFQGFSRMSS
1350
1351
EIGREKSQDW GSAGLGGVFK VEWIRKESLP FQFAHHLLNP WNDNKKVQIS
1400
1401
RDGQELEPLV GEQLLQLWER LPLGEKNTTD                      
1430
 

Show the unformatted sequence.

Checksums:
CRC64:A0C3B45771A3DE16
MD5:3f36c8e82ae8f524e6beaa8dfc050f46

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
YTH 1288 - 1419 2YU6 A 8 - 139 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.