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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PKHA3_HUMAN (Q9HB20)

Summary

This is the summary of UniProt entry PKHA3_HUMAN (Q9HB20).

Description: Pleckstrin homology domain-containing family A member 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 300 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam PH 1 93
low_complexity n/a 97 115
disorder n/a 99 101
disorder n/a 104 111
disorder n/a 137 154
disorder n/a 186 300
low_complexity n/a 194 202

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9HB20. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEGVLYKWTN YLTGWQPRWF VLDNGILSYY DSQDDVCKGS KGSIKMAVCE
50
51
IKVHSADNTR MELIIPGEQH FYMKAVNAAE RQRWLVALGS SKACLTDTRT
100
101
KKEKEISETS ESLKTKMSEL RLYCDLLMQQ VHTIQEFVHH DENHSSPSAE
150
151
NMNEASSLLS ATCNTFITTL EECVKIANAK FKPEMFQLHH PDPLVSPVSP
200
201
SPVQMMKRSV SHPGSCSSER SSHSIKEPVS TLHRLSQRRR RTYSDTDSCS
250
251
DIPLEDPDRP VHCSKNTLNG DLASATIPEE SRLMAKKQSE SEDTLPSFSS
300
301
                                                      
300
 

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Checksums:
CRC64:0B6EF45C7D17E82C
MD5:097dbc36824c3b6c3848638a051a1426

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PH 1 - 93 2KCJ A 1 - 93 Jmol OpenAstexViewer
2MDX A 9 - 101 Jmol OpenAstexViewer
3RCP A 1 - 93 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.