Summary
This is the summary of UniProt entry OTOF_HUMAN (Q9HC10).
| Description: | Otoferlin |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 1997 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam | C2 | 5 | 100 |
| disorder | n/a | 129 | 172 |
| low_complexity | n/a | 151 | 164 |
| disorder | n/a | 179 | 204 |
| disorder | n/a | 223 | 224 |
| disorder | n/a | 227 | 230 |
| disorder | n/a | 234 | 248 |
| Pfam | C2 | 254 | 357 |
| Pfam | FerI | 360 | 410 |
| disorder | n/a | 386 | 394 |
| disorder | n/a | 397 | 404 |
| Pfam | C2 | 417 | 530 |
| disorder | n/a | 584 | 599 |
| low_complexity | n/a | 608 | 619 |
| disorder | n/a | 642 | 674 |
| disorder | n/a | 676 | 691 |
| disorder | n/a | 693 | 694 |
| disorder | n/a | 745 | 749 |
| disorder | n/a | 789 | 790 |
| coiled_coil | n/a | 795 | 815 |
| Pfam | FerB | 842 | 917 |
| Pfam | C2 | 960 | 1059 |
| low_complexity | n/a | 1192 | 1203 |
| low_complexity | n/a | 1242 | 1258 |
| disorder | n/a | 1263 | 1272 |
| disorder | n/a | 1280 | 1281 |
| low_complexity | n/a | 1291 | 1323 |
| disorder | n/a | 1295 | 1324 |
| disorder | n/a | 1339 | 1408 |
| low_complexity | n/a | 1370 | 1397 |
| disorder | n/a | 1433 | 1447 |
| low_complexity | n/a | 1436 | 1447 |
| Pfam | C2 | 1492 | 1596 |
| disorder | n/a | 1617 | 1618 |
| disorder | n/a | 1630 | 1631 |
| disorder | n/a | 1636 | 1637 |
| disorder | n/a | 1641 | 1659 |
| disorder | n/a | 1685 | 1687 |
| disorder | n/a | 1689 | 1695 |
| disorder | n/a | 1718 | 1724 |
| Pfam | C2 | 1732 | 1868 |
| disorder | n/a | 1776 | 1779 |
| Pfam | Ferlin_C | 1896 | 1994 |
| low_complexity | n/a | 1908 | 1920 |
| disorder | n/a | 1925 | 1933 |
| transmembrane | n/a | 1962 | 1984 |
| low_complexity | n/a | 1965 | 1983 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9HC10. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MALLIHLKTV SELRGRGDRI AKVTFRGQSF YSRVLENCED VADFDETFRW
50 51
PVASSIDRNE MLEIQVFNYS KVFSNKLIGT FRMVLQKVVE ESHVEVTDTL
100 101
IDDNNAIIKT SLCVEVRYQA TDGTVGSWDD GDFLGDESLQ EEEKDSQETD
150 151
GLLPGSRPSS RPPGEKSFRR AGRSVFSAMK LGKNRSHKEE PQRPDEPAVL
200 201
EMEDLDHLAI RLGDGLDPDS VSLASVTALT TNVSNKRSKP DIKMEPSAGR
250 251
PMDYQVSITV IEARQLVGLN MDPVVCVEVG DDKKYTSMKE STNCPYYNEY
300 301
FVFDFHVSPD VMFDKIIKIS VIHSKNLLRS GTLVGSFKMD VGTVYSQPEH
350 351
QFHHKWAILS DPDDISSGLK GYVKCDVAVV GKGDNIKTPH KANETDEDDI
400 401
EGNLLLPEGV PPERQWARFY VKIYRAEGLP RMNTSLMANV KKAFIGENKD
450 451
LVDPYVQVFF AGQKGKTSVQ KSSYEPLWNE QVVFTDLFPP LCKRMKVQIR
500 501
DSDKVNDVAI GTHFIDLRKI SNDGDKGFLP TLGPAWVNMY GSTRNYTLLD
550 551
EHQDLNEGLG EGVSFRARLL LGLAVEIVDT SNPELTSSTE VQVEQATPIS
600 601
ESCAGKMEEF FLFGAFLEAS MIDRRNGDKP ITFEVTIGNY GNEVDGLSRP
650 651
QRPRPRKEPG DEEEVDLIQN ASDDEAGDAG DLASVSSTPP MRPQVTDRNY
700 701
FHLPYLERKP CIYIKSWWPD QRRRLYNANI MDHIADKLEE GLNDIQEMIK
750 751
TEKSYPERRL RGVLEELSCG CCRFLSLADK DQGHSSRTRL DRERLKSCMR
800 801
ELENMGQQAR MLRAQVKRHT VRDKLRLCQN FLQKLRFLAD EPQHSIPDIF
850 851
IWMMSNNKRV AYARVPSKDL LFSIVEEETG KDCAKVKTLF LKLPGKRGFG
900 901
SAGWTVQAKV ELYLWLGLSK QRKEFLCGLP CGFQEVKAAQ GLGLHAFPPV
950 951
SLVYTKKQAF QLRAHMYQAR SLFAADSSGL SDPFARVFFI NQSQCTEVLN
1000 1001
ETLCPTWDQM LVFDNLELYG EAHELRDDPP IIVIEIYDQD SMGKADFMGR
1050 1051
TFAKPLVKMA DEAYCPPRFP PQLEYYQIYR GNATAGDLLA AFELLQIGPA
1100 1101
GKADLPPING PVDVDRGPIM PVPMGIRPVL SKYRVEVLFW GLRDLKRVNL
1150 1151
AQVDRPRVDI ECAGKGVQSS LIHNYKKNPN FNTLVKWFEV DLPENELLHP
1200 1201
PLNIRVVDCR AFGRYTLVGS HAVSSLRRFI YRPPDRSAPS WNTTVRLLRR
1250 1251
CRVLCNGGSS SHSTGEVVVT MEPEVPIKKL ETMVKLDATS EAVVKVDVAE
1300 1301
EEKEKKKKKK GTAEEPEEEE PDESMLDWWS KYFASIDTMK EQLRQQEPSG
1350 1351
IDLEEKEEVD NTEGLKGSMK GKEKARAAKE EKKKKTQSSG SGQGSEAPEK
1400 1401
KKPKIDELKV YPKELESEFD NFEDWLHTFN LLRGKTGDDE DGSTEEERIV
1450 1451
GRFKGSLCVY KVPLPEDVSR EAGYDSTYGM FQGIPSNDPI NVLVRVYVVR
1500 1501
ATDLHPADIN GKADPYIAIR LGKTDIRDKE NYISKQLNPV FGKSFDIEAS
1550 1551
FPMESMLTVA VYDWDLVGTD DLIGETKIDL ENRFYSKHRA TCGIAQTYST
1600 1601
HGYNIWRDPM KPSQILTRLC KDGKVDGPHF GPPGRVKVAN RVFTGPSEIE
1650 1651
DENGQRKPTD EHVALLALRH WEDIPRAGCR LVPEHVETRP LLNPDKPGIE
1700 1701
QGRLELWVDM FPMDMPAPGT PLDISPRKPK KYELRVIIWN TDEVVLEDDD
1750 1751
FFTGEKSSDI FVRGWLKGQQ EDKQDTDVHY HSLTGEGNFN WRYLFPFDYL
1800 1801
AAEEKIVISK KESMFSWDET EYKIPARLTL QIWDADHFSA DDFLGAIELD
1850 1851
LNRFPRGAKT AKQCTMEMAT GEVDVPLVSI FKQKRVKGWW PLLARNENDE
1900 1901
FELTGKVEAE LHLLTAEEAE KNPVGLARNE PDPLEKPNRP DTSFIWFLNP
1950 1951
LKSARYFLWH TYRWLLLKLL LLLLLLLLLA LFLYSVPGYL VKKILGA
1997
Show the unformatted sequence. |
| Checksums: |
CRC64:24DE196371FB7385
MD5:42fcfb5a783ca21c8c300b4b4b7560e1
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
