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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MYO10_HUMAN (Q9HD67)

Summary

This is the summary of UniProt entry MYO10_HUMAN (Q9HD67).

Description: Unconventional myosin-X
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2058 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam SH3_19 7 58
disorder n/a 55 62
Pfam Myosin_head 65 727
disorder n/a 65 67
disorder n/a 598 607
low_complexity n/a 725 740
Pfam IQ 743 763
Pfam IQ 767 786
low_complexity n/a 776 791
Pfam IQ 789 809
coiled_coil n/a 808 936
low_complexity n/a 808 854
disorder n/a 819 853
disorder n/a 859 866
disorder n/a 873 879
Pfam MYO10_CC 882 933
disorder n/a 902 918
low_complexity n/a 915 932
disorder n/a 920 924
low_complexity n/a 924 939
disorder n/a 927 930
disorder n/a 967 972
disorder n/a 974 1098
low_complexity n/a 1059 1070
low_complexity n/a 1085 1097
disorder n/a 1100 1103
low_complexity n/a 1142 1160
disorder n/a 1149 1150
Pfam PH 1213 1310
disorder n/a 1313 1328
Pfam PH 1393 1497
low_complexity n/a 1536 1547
Pfam MyTH4 1586 1694
Pfam RA 1700 1769
Pfam FERM_M 1793 1958
low_complexity n/a 2045 2057
disorder n/a 2052 2058

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9HD67. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDNFFTEGTR VWLRENGQHF PSTVNSCAEG IVVFRTDYGQ VFTYKQSTIT
50
51
HQKVTAMHPT NEEGVDDMAS LTELHGGSIM YNLFQRYKRN QIYTYIGSIL
100
101
ASVNPYQPIA GLYEPATMEQ YSRRHLGELP PHIFAIANEC YRCLWKRHDN
150
151
QCILISGESG AGKTESTKLI LKFLSVISQQ SLELSLKEKT SCVERAILES
200
201
SPIMEAFGNA KTVYNNNSSR FGKFVQLNIC QKGNIQGGRI VDYLLEKNRV
250
251
VRQNPGERNY HIFYALLAGL EHEEREEFYL STPENYHYLN QSGCVEDKTI
300
301
SDQESFREVI TAMDVMQFSK EEVREVSRLL AGILHLGNIE FITAGGAQVS
350
351
FKTALGRSAE LLGLDPTQLT DALTQRSMFL RGEEILTPLN VQQAVDSRDS
400
401
LAMALYACCF EWVIKKINSR IKGNEDFKSI GILDIFGFEN FEVNHFEQFN
450
451
INYANEKLQE YFNKHIFSLE QLEYSREGLV WEDIDWIDNG ECLDLIEKKL
500
501
GLLALINEES HFPQATDSTL LEKLHSQHAN NHFYVKPRVA VNNFGVKHYA
550
551
GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL
600
601
KCGSKHRRPT VSSQFKDSLH SLMATLSSSN PFFVRCIKPN MQKMPDQFDQ
650
651
AVVLNQLRYS GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNLALPEDVR
700
701
GKCTSLLQLY DASNSEWQLG KTKVFLRESL EQKLEKRREE EVSHAAMVIR
750
751
AHVLGFLARK QYRKVLYCVV IIQKNYRAFL LRRRFLHLKK AAIVFQKQLR
800
801
GQIARRVYRQ LLAEKREQEE KKKQEEEEKK KREEEERERE RERREAELRA
850
851
QQEEETRKQQ ELEALQKSQK EAELTRELEK QKENKQVEEI LRLEKEIEDL
900
901
QRMKEQQELS LTEASLQKLQ ERRDQELRRL EEEACRAAQE FLESLNFDEI
950
951
DECVRNIERS LSVGSEFSSE LAESACEEKP NFNFSQPYPE EEVDEGFEAD
1000
1001
DDAFKDSPNP SEHGHSDQRT SGIRTSDDSS EEDPYMNDTV VPTSPSADST
1050
1051
VLLAPSVQDS GSLHNSSSGE STYCMPQNAG DLPSPDGDYD YDQDDYEDGA
1100
1101
ITSGSSVTFS NSYGSQWSPD YRCSVGTYNS SGAYRFSSEG AQSSFEDSEE
1150
1151
DFDSRFDTDD ELSYRRDSVY SCVTLPYFHS FLYMKGGLMN SWKRRWCVLK
1200
1201
DETFLWFRSK QEALKQGWLH KKGGGSSTLS RRNWKKRWFV LRQSKLMYFE
1250
1251
NDSEEKLKGT VEVRTAKEII DNTTKENGID IIMADRTFHL IAESPEDASQ
1300
1301
WFSVLSQVHA STDQEIQEMH DEQANPQNAV GTLDVGLIDS VCASDSPDRP
1350
1351
NSFVIITANR VLHCNADTPE EMHHWITLLQ RSKGDTRVEG QEFIVRGWLH
1400
1401
KEVKNSPKMS SLKLKKRWFV LTHNSLDYYK SSEKNALKLG TLVLNSLCSV
1450
1451
VPPDEKIFKE TGYWNVTVYG RKHCYRLYTK LLNEATRWSS AIQNVTDTKA
1500
1501
PIDTPTQQLI QDIKENCLNS DVVEQIYKRN PILRYTHHPL HSPLLPLPYG
1550
1551
DINLNLLKDK GYTTLQDEAI KIFNSLQQLE SMSDPIPIIQ GILQTGHDLR
1600
1601
PLRDELYCQL IKQTNKVPHP GSVGNLYSWQ ILTCLSCTFL PSRGILKYLK
1650
1651
FHLKRIREQF PGSEMEKYAL FTYESLKKTK CREFVPSRDE IEALIHRQEM
1700
1701
TSTVYCHGGG SCKITINSHT TAGEVVEKLI RGLAMEDSRN MFALFEYNGH
1750
1751
VDKAIESRTV VADVLAKFEK LAATSEVGDL PWKFYFKLYC FLDTDNVPKD
1800
1801
SVEFAFMFEQ AHEAVIHGHH PAPEENLQVL AALRLQYLQG DYTLHAAIPP
1850
1851
LEEVYSLQRL KARISQSTKT FTPCERLEKR RTSFLEGTLR RSFRTGSVVR
1900
1901
QKVEEEQMLD MWIKEEVSSA RASIIDKWRK FQGMNQEQAM AKYMALIKEW
1950
1951
PGYGSTLFDV ECKEGGFPQE LWLGVSADAV SVYKRGEGRP LEVFQYEHIL
2000
2001
SFGAPLANTY KIVVDERELL FETSEVVDVA KLMKAYISMI VKKRYSTTRS
2050
2051
ASSQGSSR                                              
2058
 

Show the unformatted sequence.

Checksums:
CRC64:269C9E6566BD6D0B
MD5:9feea98fe35649f4b6821b9288d8effb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FERM_M 1793 - 1958 3AU4 A 1793 - 1958 Jmol OpenAstexViewer
3AU5 A 1793 - 1958 Jmol OpenAstexViewer
B 1793 - 1958 Jmol OpenAstexViewer
3PZD A 1793 - 1958 Jmol OpenAstexViewer
IQ 743 - 763 5I0I A 743 - 763 Jmol OpenAstexViewer
B 743 - 763 Jmol OpenAstexViewer
767 - 786 5I0I A 767 - 786 Jmol OpenAstexViewer
B 767 - 786 Jmol OpenAstexViewer
MYO10_CC 883 - 933 2LW9 A 1 - 51 Jmol OpenAstexViewer
B 53 - 103 Jmol OpenAstexViewer
Myosin_head 65 - 727 5I0H A 65 - 727 Jmol OpenAstexViewer
B 65 - 727 Jmol OpenAstexViewer
5I0I A 65 - 727 Jmol OpenAstexViewer
B 65 - 727 Jmol OpenAstexViewer
66 - 727 5KG8 A 66 - 727 Jmol OpenAstexViewer
MyTH4 1586 - 1694 3AU4 A 1586 - 1694 Jmol OpenAstexViewer
3AU5 A 1586 - 1694 Jmol OpenAstexViewer
B 1586 - 1694 Jmol OpenAstexViewer
3PZD A 1586 - 1694 Jmol OpenAstexViewer
RA 1700 - 1769 3AU4 A 1700 - 1769 Jmol OpenAstexViewer
3AU5 A 1700 - 1769 Jmol OpenAstexViewer
B 1700 - 1769 Jmol OpenAstexViewer
3PZD A 1700 - 1769 Jmol OpenAstexViewer
SH3_19 7 - 58 5I0H A 7 - 58 Jmol OpenAstexViewer
B 7 - 58 Jmol OpenAstexViewer
5I0I A 7 - 58 Jmol OpenAstexViewer
B 7 - 58 Jmol OpenAstexViewer
5KG8 A 7 - 58 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.