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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CD2AP_MOUSE (Q9JLQ0)

Summary

This is the summary of UniProt entry CD2AP_MOUSE (Q9JLQ0).

Description: CD2-associated protein
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 637 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam SH3_9 6 55
disorder n/a 53 56
disorder n/a 60 62
disorder n/a 64 73
disorder n/a 92 104
low_complexity n/a 102 114
Pfam SH3_9 115 163
low_complexity n/a 127 144
disorder n/a 161 208
low_complexity n/a 183 195
disorder n/a 227 265
low_complexity n/a 231 243
Pfam SH3_1 275 322
disorder n/a 291 296
disorder n/a 310 313
disorder n/a 320 535
low_complexity n/a 336 352
low_complexity n/a 377 399
low_complexity n/a 410 422
low_complexity n/a 536 555
disorder n/a 539 550
disorder n/a 552 553
disorder n/a 572 579
coiled_coil n/a 581 633
low_complexity n/a 604 617
disorder n/a 605 613

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9JLQ0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP
50
51
DNFVKEIKRE TEPKDDNLPI KRERQGNVAS LVQRISTYGL PAGGIQPHPQ
100
101
TKAIKKKTKK RQCKVLFDYS PQNEDELELI VGDVIDVIEE VEEGWWSGTL
150
151
NNKLGLFPSN FVKELESTED GETHNAQEES EVPLTGPTSP LPSPGNGSEP
200
201
APGSVAQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK TEKPLILQPL
250
251
GSRTQNVEVT KPDVDGKIKA KEYCRTLFPY TGTNEDELTF REGEIIHLIS
300
301
KETGEAGWWK GELNGKEGVF PDNFAVQISE LDKDFPKPKK PPPPAKGPAP
350
351
KPDLSAAEKK AFPLKAEEKD EKSLLEQKPS KPAAPQVPPK KPTAPTKASN
400
401
LLRSPGAVYP KRPEKPVPPP PPAAKINGEV SIISSKIDTE PVSKPKLDPE
450
451
QLPVRPKSVD LDAFVARNSK ETDDVNFDDI ASSENLLHLT ANRPKMPGRR
500
501
LPGRFNGGHS PTQSPEKTLK LPKEDDSGNL KPLEFKKDAS YSSKSSLSTP
550
551
SSASKVNTAA FLTPLELKAK AEADDGKRNS VDELRAQIIE LLCIVDALKK
600
601
DHGKELEKLR KELEEEKAMR SNLEVEIAKL KKAVLLS              
637
 

Show the unformatted sequence.

Checksums:
CRC64:0B618FE82AF12332
MD5:16a2b00b08d23f43756c3976ef15e6d3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH3_1 275 - 322 2JTE A 10 - 57 Show 3D Structure View in InterPro
2KRO A 10 - 57 Show 3D Structure View in InterPro
2LZ6 B 10 - 57 Show 3D Structure View in InterPro
SH3_9 115 - 163 2KRN A 9 - 57 Show 3D Structure View in InterPro
6 - 55 2KRM A 6 - 55 Show 3D Structure View in InterPro
2MCN A 6 - 55 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;