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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NLRC4_HUMAN (Q9NPP4)

Summary

This is the summary of UniProt entry NLRC4_HUMAN (Q9NPP4).

Description: NLR family CARD domain-containing protein 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1024 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam CARD 1 87
low_complexity n/a 96 107
Pfam NACHT 163 316
low_complexity n/a 235 246
Pfam NLRC4_HD 465 579

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NPP4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNFIKDNSRA LIQRMGMTVI KQITDDLFVW NVLNREEVNI ICCEKVEQDA
50
51
ARGIIHMILK KGSESCNLFL KSLKEWNYPL FQDLNGQSLF HQTSEGDLDD
100
101
LAQDLKDLYH TPSFLNFYPL GEDIDIIFNL KSTFTEPVLW RKDQHHHRVE
150
151
QLTLNGLLQA LQSPCIIEGE SGKGKSTLLQ RIAMLWGSGK CKALTKFKFV
200
201
FFLRLSRAQG GLFETLCDQL LDIPGTIRKQ TFMAMLLKLR QRVLFLLDGY
250
251
NEFKPQNCPE IEALIKENHR FKNMVIVTTT TECLRHIRQF GALTAEVGDM
300
301
TEDSAQALIR EVLIKELAEG LLLQIQKSRC LRNLMKTPLF VVITCAIQMG
350
351
ESEFHSHTQT TLFHTFYDLL IQKNKHKHKG VAASDFIRSL DHCGDLALEG
400
401
VFSHKFDFEL QDVSSVNEDV LLTTGLLCKY TAQRFKPKYK FFHKSFQEYT
450
451
AGRRLSSLLT SHEPEEVTKG NGYLQKMVSI SDITSTYSSL LRYTCGSSVE
500
501
ATRAVMKHLA AVYQHGCLLG LSIAKRPLWR QESLQSVKNT TEQEILKAIN
550
551
INSFVECGIH LYQESTSKSA LSQEFEAFFQ GKSLYINSGN IPDYLFDFFE
600
601
HLPNCASALD FIKLDFYGGA MASWEKAAED TGGIHMEEAP ETYIPSRAVS
650
651
LFFNWKQEFR TLEVTLRDFS KLNKQDIRYL GKIFSSATSL RLQIKRCAGV
700
701
AGSLSLVLST CKNIYSLMVE ASPLTIEDER HITSVTNLKT LSIHDLQNQR
750
751
LPGGLTDSLG NLKNLTKLIM DNIKMNEEDA IKLAEGLKNL KKMCLFHLTH
800
801
LSDIGEGMDY IVKSLSSEPC DLEEIQLVSC CLSANAVKIL AQNLHNLVKL
850
851
SILDLSENYL EKDGNEALHE LIDRMNVLEQ LTALMLPWGC DVQGSLSSLL
900
901
KHLEEVPQLV KLGLKNWRLT DTEIRILGAF FGKNPLKNFQ QLNLAGNRVS
950
951
SDGWLAFMGV FENLKQLVFF DFSTKEFLPD PALVRKLSQV LSKLTFLQEA
1000
1001
RLVGWQFDDD DLSVITGAFK LVTA                            
1024
 

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Checksums:
CRC64:49378DBB54938E0F
MD5:769e1993b1d57a1e587581c124f86c7d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CARD 1 - 85 6N1I A 1 - 85 Jmol OpenAstexViewer
B 1 - 85 Jmol OpenAstexViewer
C 1 - 85 Jmol OpenAstexViewer
D 1 - 85 Jmol OpenAstexViewer
E 1 - 85 Jmol OpenAstexViewer
F 1 - 85 Jmol OpenAstexViewer
G 1 - 85 Jmol OpenAstexViewer
H 1 - 85 Jmol OpenAstexViewer
I 1 - 85 Jmol OpenAstexViewer
J 1 - 85 Jmol OpenAstexViewer
K 1 - 85 Jmol OpenAstexViewer
L 1 - 85 Jmol OpenAstexViewer
M 1 - 85 Jmol OpenAstexViewer
N 1 - 85 Jmol OpenAstexViewer
O 1 - 85 Jmol OpenAstexViewer
P 1 - 85 Jmol OpenAstexViewer
1 - 87 6MKS a 1 - 87 Jmol OpenAstexViewer
A 1 - 87 Jmol OpenAstexViewer
B 1 - 87 Jmol OpenAstexViewer
b 1 - 87 Jmol OpenAstexViewer
c 1 - 87 Jmol OpenAstexViewer
C 1 - 87 Jmol OpenAstexViewer
d 1 - 87 Jmol OpenAstexViewer
D 1 - 87 Jmol OpenAstexViewer
E 1 - 87 Jmol OpenAstexViewer
e 1 - 87 Jmol OpenAstexViewer
F 1 - 87 Jmol OpenAstexViewer
G 1 - 87 Jmol OpenAstexViewer
H 1 - 87 Jmol OpenAstexViewer
I 1 - 87 Jmol OpenAstexViewer
J 1 - 87 Jmol OpenAstexViewer
K 1 - 87 Jmol OpenAstexViewer
L 1 - 87 Jmol OpenAstexViewer
M 1 - 87 Jmol OpenAstexViewer
N 1 - 87 Jmol OpenAstexViewer
O 1 - 87 Jmol OpenAstexViewer
P 1 - 87 Jmol OpenAstexViewer
Q 1 - 87 Jmol OpenAstexViewer
R 1 - 87 Jmol OpenAstexViewer
S 1 - 87 Jmol OpenAstexViewer
T 1 - 87 Jmol OpenAstexViewer
U 1 - 87 Jmol OpenAstexViewer
V 1 - 87 Jmol OpenAstexViewer
W 1 - 87 Jmol OpenAstexViewer
X 1 - 87 Jmol OpenAstexViewer
Y 1 - 87 Jmol OpenAstexViewer
Z 1 - 87 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.