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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TF7L2_HUMAN (Q9NQB0)

Summary

This is the summary of UniProt entry TF7L2_HUMAN (Q9NQB0).

Description: Transcription factor 7-like 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 619 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 95
low_complexity n/a 4 16
Pfam CTNNB1_binding 5 259
low_complexity n/a 58 74
disorder n/a 116 135
disorder n/a 167 188
low_complexity n/a 188 199
disorder n/a 202 247
low_complexity n/a 230 244
disorder n/a 253 259
disorder n/a 261 262
disorder n/a 270 274
disorder n/a 280 285
disorder n/a 287 352
low_complexity n/a 332 352
Pfam HMG_box 350 418
disorder n/a 420 438
low_complexity n/a 425 433
disorder n/a 463 464
low_complexity n/a 494 521
disorder n/a 499 561
low_complexity n/a 542 560
disorder n/a 567 619
low_complexity n/a 572 597
low_complexity n/a 593 603

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NQB0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
50
51
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
100
101
PGYPFIMIPD LTSPYLPNGS LSPTARTLHF QSGSTHYSAY KTIEHQIAVQ
150
151
YLQMKWPLLD VQAGSLQSRQ ALKDARSPSP AHIVSNKVPV VQHPHHVHPL
200
201
TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS PYYPLSPGTV
250
251
GQIPHPLGWL VPQQGQPVYP ITTGGFRHPY PTALTVNASM SRFPPHMVPP
300
301
HHTLHTTGIP HPAIVTPTVK QESSQSDVGS LHSSKHQDSK KEEEKKKPHI
350
351
KKPLNAFMLY MKEMRAKVVA ECTLKESAAI NQILGRRWHA LSREEQAKYY
400
401
ELARKERQLH MQLYPGWSAR DNYGKKKKRK RDKQPGETNE HSECFLNPCL
450
451
SLPPITDLSA PKKCRARFGL DQQNNWCGPC RRKKKCVRYI QGEGSCLSPP
500
501
SSDGSLLDSP PPSPNLLGSP PRDAKSQTEQ TQPLSLSLKP DPLAHLSMMP
550
551
PPPALLLAEA THKASALCPN GALDLPPAAL QPAAPSSSIA QPSTSSLHSH
600
601
SSLAGTQPQP LSLVTKSLE                                  
619
 

Show the unformatted sequence.

Checksums:
CRC64:4DD2D3CC814AE16E
MD5:fa6401582ffc2a55a02455f4f436e3f2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CTNNB1_binding 12 - 49 1JDH B 12 - 49 Show 3D Structure View in InterPro
12 - 50 2GL7 B 12 - 50 Show 3D Structure View in InterPro
E 12 - 50 Show 3D Structure View in InterPro
13 - 50 1JPW D 13 - 50 Show 3D Structure View in InterPro
E 13 - 50 Show 3D Structure View in InterPro
F 13 - 50 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;