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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: EXOS5_HUMAN (Q9NQT4)

Summary

This is the summary of UniProt entry EXOS5_HUMAN (Q9NQT4).

Description: Exosome complex component RRP46
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 235 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 21
disorder n/a 23 25
Pfam RNase_PH 27 147
low_complexity n/a 128 140
Pfam RNase_PH_C 150 216
low_complexity n/a 205 217

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NQT4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEEETHTDAK IRAENGTGSS PRGPGCSLRH FACEQNLLSR PDGSASFLQG
50
51
DTSVLAGVYG PAEVKVSKEI FNKATLEVIL RPKIGLPGVA EKSRERLIRN
100
101
TCEAVVLGTL HPRTSITVVL QVVSDAGSLL ACCLNAACMA LVDAGVPMRA
150
151
LFCGVACALD SDGTLVLDPT SKQEKEARAV LTFALDSVER KLLMSSTKGL
200
201
YSDTELQQCL AAAQAASQHV FRFYRESLQR RYSKS                
235
 

Show the unformatted sequence.

Checksums:
CRC64:C3C1FCB39D85B1EE
MD5:b840394f0d28d161d990daf60ba644e5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RNase_PH 27 - 147 2NN6 D 27 - 147 Jmol OpenAstexViewer
RNase_PH_C 150 - 216 2NN6 D 150 - 216 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.