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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PRDM9_HUMAN (Q9NQV7)

Summary

This is the summary of UniProt entry PRDM9_HUMAN (Q9NQV7).

Description: Histone-lysine N-methyltransferase PRDM9 EC=2.1.1.43
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 894 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 23
low_complexity n/a 2 19
Pfam KRAB 27 65
Pfam SET 64 358
disorder n/a 77 114
disorder n/a 116 128
disorder n/a 135 192
low_complexity n/a 165 178
coiled_coil n/a 166 186
Pfam SSXRD 171 201
disorder n/a 224 246
disorder n/a 408 464
disorder n/a 468 477
disorder n/a 479 481
disorder n/a 483 509
Pfam zf-C2H2 552 574
Pfam zf-C2H2 580 602
Pfam zf-C2H2 608 630
Pfam zf-C2H2 636 658
Pfam zf-C2H2 664 686
Pfam zf-C2H2 692 714
Pfam zf-C2H2 720 742
disorder n/a 736 738
Pfam zf-C2H2 748 770
disorder n/a 764 766
Pfam zf-C2H2 776 798
disorder n/a 792 794
Pfam zf-C2H2 804 826
disorder n/a 820 822
Pfam zf-C2H2 832 854
disorder n/a 848 850
Pfam zf-C2H2 860 882

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NQV7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSPEKSQEES PEEDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR
50
51
YRNVKRNYNA LITIGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ
100
101
VKPPWMALRV EQRKHQKGMP KASFSNESSL KELSRTANLL NASGSEQAQK
150
151
PVSPSGEAST SGQHSRLKLE LRKKETERKM YSLRERKGHA YKEVSEPQDD
200
201
DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL SLPPGLRIGP
250
251
SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANNG YSWLITKGRN
300
301
CYEYVDGKDK SWANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG
350
351
CELLVWYGDE YGQELGIKWG SKWKKELMAG REPKPEIHPC PSCCLAFSSQ
400
401
KFLSQHVERN HSSQNFPGPS ARKLLQPENP CPGDQNQEQQ YPDPHSRNDK
450
451
TKGQEIKERS KLLNKRTWQR EISRAFSSPP KGQMGSCRVG KRIMEEESRT
500
501
GQKVNPGNTG KLFVGVGISR IAKVKYGECG QGFSVKSDVI THQRTHTGEK
550
551
LYVCRECGRG FSWKSHLLIH QRIHTGEKPY VCRECGRGFS WQSVLLTHQR
600
601
THTGEKPYVC RECGRGFSRQ SVLLTHQRRH TGEKPYVCRE CGRGFSRQSV
650
651
LLTHQRRHTG EKPYVCRECG RGFSWQSVLL THQRTHTGEK PYVCRECGRG
700
701
FSWQSVLLTH QRTHTGEKPY VCRECGRGFS NKSHLLRHQR THTGEKPYVC
750
751
RECGRGFRDK SHLLRHQRTH TGEKPYVCRE CGRGFRDKSN LLSHQRTHTG
800
801
EKPYVCRECG RGFSNKSHLL RHQRTHTGEK PYVCRECGRG FRNKSHLLRH
850
851
QRTHTGEKPY VCRECGRGFS DRSSLCYHQR THTGEKPYVC REDE      
894
 

Show the unformatted sequence.

Checksums:
CRC64:DE53094C32EFF83B
MD5:17e3efd9ddeacd10afb1da912d3cf72a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SET 195 - 358 4IJD A 195 - 358 Jmol OpenAstexViewer
B 195 - 358 Jmol OpenAstexViewer
SSXRD 195 - 201 4IJD A 195 - 201 Jmol OpenAstexViewer
B 195 - 201 Jmol OpenAstexViewer
zf-C2H2 720 - 742 5EGB A 719 - 741 Jmol OpenAstexViewer
5EH2 E 719 - 741 Jmol OpenAstexViewer
F 719 - 741 Jmol OpenAstexViewer
5EI9 E 719 - 741 Jmol OpenAstexViewer
F 719 - 741 Jmol OpenAstexViewer
748 - 770 5EGB A 747 - 769 Jmol OpenAstexViewer
5EH2 E 747 - 769 Jmol OpenAstexViewer
F 747 - 769 Jmol OpenAstexViewer
5EI9 E 747 - 769 Jmol OpenAstexViewer
F 747 - 769 Jmol OpenAstexViewer
776 - 798 5EGB A 775 - 797 Jmol OpenAstexViewer
5EH2 E 775 - 797 Jmol OpenAstexViewer
F 775 - 797 Jmol OpenAstexViewer
5EI9 E 775 - 797 Jmol OpenAstexViewer
F 775 - 797 Jmol OpenAstexViewer
804 - 826 5EGB A 803 - 825 Jmol OpenAstexViewer
5EH2 E 803 - 825 Jmol OpenAstexViewer
F 803 - 825 Jmol OpenAstexViewer
5EI9 E 803 - 825 Jmol OpenAstexViewer
F 803 - 825 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.