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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DISC1_HUMAN (Q9NRI5)

Summary

This is the summary of UniProt entry DISC1_HUMAN (Q9NRI5).

Description: Disrupted in schizophrenia 1 protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 854 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 22
low_complexity n/a 1 16
low_complexity n/a 26 42
disorder n/a 39 42
disorder n/a 44 52
disorder n/a 67 87
low_complexity n/a 68 80
disorder n/a 99 108
disorder n/a 114 116
disorder n/a 119 120
disorder n/a 133 135
disorder n/a 143 152
disorder n/a 158 159
disorder n/a 174 176
disorder n/a 178 179
disorder n/a 182 204
low_complexity n/a 188 200
disorder n/a 221 257
disorder n/a 277 318
low_complexity n/a 292 308
low_complexity n/a 310 321
disorder n/a 320 321
disorder n/a 323 325
disorder n/a 364 378
coiled_coil n/a 366 393
disorder n/a 416 442
disorder n/a 444 445
coiled_coil n/a 455 496
low_complexity n/a 457 473
low_complexity n/a 483 499
disorder n/a 530 531
coiled_coil n/a 543 563
coiled_coil n/a 604 624
low_complexity n/a 612 638
coiled_coil n/a 639 666
disorder n/a 657 667
disorder n/a 716 741
disorder n/a 743 744
coiled_coil n/a 808 828
disorder n/a 829 830
disorder n/a 837 846

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NRI5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPGGGPQGAP AAAGGGGVSH RAGSRDCLPP AACFRRRRLA RRPGYMRSST
50
51
GPGIGFLSPA VGTLFRFPGG VSGEESHHSE SRARQCGLDS RGLLVRSPVS
100
101
KSAAAPTVTS VRGTSAHFGI QLRGGTRLPD RLSWPCGPGS AGWQQEFAAM
150
151
DSSETLDASW EAACSDGARR VRAAGSLPSA ELSSNSCSPG CGPEVPPTPP
200
201
GSHSAFTSSF SFIRLSLGSA GERGEAEGCP PSREAESHCQ SPQEMGAKAA
250
251
SLDGPHEDPR CLSRPFSLLA TRVSADLAQA ARNSSRPERD MHSLPDMDPG
300
301
SSSSLDPSLA GCGGDGSSGS GDAHSWDTLL RKWEPVLRDC LLRNRRQMEV
350
351
ISLRLKLQKL QEDAVENDDY DKAETLQQRL EDLEQEKISL HFQLPSRQPA
400
401
LSSFLGHLAA QVQAALRRGA TQQASGDDTH TPLRMEPRLL EPTAQDSLHV
450
451
SITRRDWLLQ EKQQLQKEIE ALQARMFVLE AKDQQLRREI EEQEQQLQWQ
500
501
GCDLTPLVGQ LSLGQLQEVS KALQDTLASA GQIPFHAEPP ETIRSLQERI
550
551
KSLNLSLKEI TTKVCMSEKF CSTLRKKVND IETQLPALLE AKMHAISGNH
600
601
FWTAKDLTEE IRSLTSEREG LEGLLSKLLV LSSRNVKKLG SVKEDYNRLR
650
651
REVEHQETAY ETSVKENTMK YMETLKNKLC SCKCPLLGKV WEADLEACRL
700
701
LIQSLQLQEA RGSLSVEDER QMDDLEGAAP PIPPRLHSED KRKTPLKVLE
750
751
EWKTHLIPSL HCAGGEQKEE SYILSAELGE KCEDIGKKLL YLEDQLHTAI
800
801
HSHDEDLIQS LRRELQMVKE TLQAMILQLQ PAKEAGEREA AASCMTAGVH
850
851
EAQA                                                  
854
 

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Checksums:
CRC64:63C3FDF2F59830C6
MD5:465dde6cbe07f25c795d494265aa44e7

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.