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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DUS22_HUMAN (Q9NRW4)

Summary

This is the summary of UniProt entry DUS22_HUMAN (Q9NRW4).

Description: Dual specificity protein phosphatase 22 EC=3.1.3.16 EC=3.1.3.48
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 184 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam DSPc 12 141

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NRW4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY
50
51
LCIPAADSPS QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI
100
101
AYIMTVTDFG WEDALHTVRA GRSCANPNVG FQRQLQEFEK HEVHQYRQWL
150
151
KEEYGESPLQ DAEEAKNILA APGILKFWAF LRRL                 
184
 

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Checksums:
CRC64:B3F962A087C2BA20
MD5:a6464a3a8152c5f31d874cee415f158b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DSPc 12 - 141 1WRM A 12 - 141 Jmol OpenAstexViewer
4WOH A 12 - 141 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.