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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RGS18_HUMAN (Q9NS28)

Summary

This is the summary of UniProt entry RGS18_HUMAN (Q9NS28).

Description: Regulator of G-protein signaling 18
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 235 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 33 39
disorder n/a 61 71
disorder n/a 74 75
Pfam RGS 86 201
disorder n/a 210 215

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NS28. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
METTLLFFSQ INMCESKEKT FFKLIHGSGK EETSKEAKIR AKEKRNRLSL
50
51
LVQKPEFHED TRSSRSGHLA KETRVSPEEA VKWGESFDKL LSHRDGLEAF
100
101
TRFLKTEFSE ENIEFWIACE DFKKSKGPQQ IHLKAKAIYE KFIQTDAPKE
150
151
VNLDFHTKEV ITNSITQPTL HSFDAAQSRV YQLMEQDSYT RFLKSDIYLD
200
201
LMEGRPQRPT NLRRRSRSFT CNEFQDVQSD VAIWL                
235
 

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Checksums:
CRC64:973ABDE8EC7DE3D5
MD5:4c2a21b8dab6e81484183f755a27c102

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RGS 86 - 201 2DLV A 18 - 133 Jmol OpenAstexViewer
2JM5 A 14 - 129 Jmol OpenAstexViewer
2OWI A 14 - 129 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.