Summary
This is the summary of UniProt entry RNF12_HUMAN (Q9NVW2).
| Description: | E3 ubiquitin-protein ligase RLIM EC=2.3.2.27 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 624 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 34 |
| disorder | n/a | 37 | 40 |
| disorder | n/a | 44 | 327 |
| low_complexity | n/a | 85 | 97 |
| low_complexity | n/a | 142 | 159 |
| low_complexity | n/a | 209 | 225 |
| low_complexity | n/a | 219 | 230 |
| disorder | n/a | 331 | 370 |
| disorder | n/a | 377 | 378 |
| disorder | n/a | 386 | 387 |
| disorder | n/a | 389 | 406 |
| disorder | n/a | 417 | 522 |
| low_complexity | n/a | 442 | 490 |
| low_complexity | n/a | 494 | 513 |
| disorder | n/a | 540 | 556 |
| Pfam | zf-RING_2 | 568 | 611 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NVW2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN
50 51
NLLGTPGEST EEELLRRLQQ IKEGPPPQNS DENRGGDSSD DVSNGDSIID
100 101
WLNSVRQTGN TTRSGQRGNQ SWRAVSRTNP NSGDFRFSLE INVNRNNGSQ
150 151
NSENENEPSA RRSSGENVEN NSQRQVENPR SESTSARPSR SERNSTEALT
200 201
EVPPTRGQRR ARSRSPDHRR TRARAERSRS PLHPMSEIPR RSHHSISSQT
250 251
FEHPLVNETE GSSRTRHHVT LRQQISGPEL LSRGLFAASG TRNASQGAGS
300 301
SDTAASGEST GSGQRPPTIV LDLQVRRVRP GEYRQRDSIA SRTRSRSQTP
350 351
NNTVTYESER GGFRRTFSRS ERAGVRTYVS TIRIPIRRIL NTGLSETTSV
400 401
AIQTMLRQIM TGFGELSYFM YSDSDSEPTG SVSNRNMERA ESRSGRGGSG
450 451
GGSSSGSSSS SSSSSSSSSS SSSSSSPSSS SGGESSETSS DLFEGSNEGS
500 501
SSSGSSGARR EGRHRAPVTF DESGSLPFLS LAQFFLLNED DDDQPRGLTK
550 551
EQIDNLAMRS FGENDALKTC SVCITEYTEG NKLRKLPCSH EYHVHCIDRW
600 601
LSENSTCPIC RRAVLASGNR ESVV
624
Show the unformatted sequence. |
| Checksums: |
CRC64:4D583FA6872B51D3
MD5:b17d418ac9a168f37fed40159d7eb7b3
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| zf-RING_2 | 568 - 611 | 6W7Z | B | 568 - 611 | NGL View in InterPro |
| 6W9A | B | 568 - 611 | NGL View in InterPro | ||
| D | 568 - 611 | NGL View in InterPro | |||
| 6W9D | B | 568 - 611 | NGL View in InterPro | ||
| E | 568 - 611 | NGL View in InterPro | |||
| H | 568 - 611 | NGL View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in yellow.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
