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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RNF12_HUMAN (Q9NVW2)

Summary

This is the summary of UniProt entry RNF12_HUMAN (Q9NVW2).

Description: E3 ubiquitin-protein ligase RLIM EC=2.3.2.27
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 624 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 34
disorder n/a 37 40
disorder n/a 44 327
low_complexity n/a 85 97
low_complexity n/a 142 159
low_complexity n/a 209 225
low_complexity n/a 219 230
disorder n/a 331 370
disorder n/a 377 378
disorder n/a 386 387
disorder n/a 389 406
disorder n/a 417 522
low_complexity n/a 442 490
low_complexity n/a 494 513
disorder n/a 540 556
Pfam zf-RING_2 568 611

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NVW2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN
50
51
NLLGTPGEST EEELLRRLQQ IKEGPPPQNS DENRGGDSSD DVSNGDSIID
100
101
WLNSVRQTGN TTRSGQRGNQ SWRAVSRTNP NSGDFRFSLE INVNRNNGSQ
150
151
NSENENEPSA RRSSGENVEN NSQRQVENPR SESTSARPSR SERNSTEALT
200
201
EVPPTRGQRR ARSRSPDHRR TRARAERSRS PLHPMSEIPR RSHHSISSQT
250
251
FEHPLVNETE GSSRTRHHVT LRQQISGPEL LSRGLFAASG TRNASQGAGS
300
301
SDTAASGEST GSGQRPPTIV LDLQVRRVRP GEYRQRDSIA SRTRSRSQTP
350
351
NNTVTYESER GGFRRTFSRS ERAGVRTYVS TIRIPIRRIL NTGLSETTSV
400
401
AIQTMLRQIM TGFGELSYFM YSDSDSEPTG SVSNRNMERA ESRSGRGGSG
450
451
GGSSSGSSSS SSSSSSSSSS SSSSSSPSSS SGGESSETSS DLFEGSNEGS
500
501
SSSGSSGARR EGRHRAPVTF DESGSLPFLS LAQFFLLNED DDDQPRGLTK
550
551
EQIDNLAMRS FGENDALKTC SVCITEYTEG NKLRKLPCSH EYHVHCIDRW
600
601
LSENSTCPIC RRAVLASGNR ESVV                            
624
 

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Checksums:
CRC64:4D583FA6872B51D3
MD5:b17d418ac9a168f37fed40159d7eb7b3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
zf-RING_2 568 - 611 6W7Z B 568 - 611 NGL View in InterPro
6W9A B 568 - 611 NGL View in InterPro
D 568 - 611 NGL View in InterPro
6W9D B 568 - 611 NGL View in InterPro
E 568 - 611 NGL View in InterPro
H 568 - 611 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.