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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SCN3A_HUMAN (Q9NY46)

Summary

This is the summary of UniProt entry SCN3A_HUMAN (Q9NY46).

Description: Sodium channel protein type 3 subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2000 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
coiled_coil n/a 22 42
low_complexity n/a 23 40
disorder n/a 28 53
transmembrane n/a 124 147
Pfam Ion_trans 127 435
transmembrane n/a 195 215
transmembrane n/a 227 244
transmembrane n/a 250 270
transmembrane n/a 400 427
coiled_coil n/a 424 465
low_complexity n/a 432 447
disorder n/a 436 440
disorder n/a 446 447
low_complexity n/a 446 469
low_complexity n/a 473 498
disorder n/a 493 527
low_complexity n/a 500 509
Pfam Na_trans_cytopl 558 710
disorder n/a 563 566
disorder n/a 577 581
disorder n/a 588 601
disorder n/a 603 642
disorder n/a 661 683
Pfam Ion_trans 759 994
transmembrane n/a 761 779
transmembrane n/a 791 814
transmembrane n/a 826 850
low_complexity n/a 847 859
transmembrane n/a 871 899
low_complexity n/a 887 899
transmembrane n/a 929 949
transmembrane n/a 961 984
low_complexity n/a 972 994
Pfam Na_trans_assoc 998 1201
disorder n/a 1068 1070
low_complexity n/a 1069 1080
disorder n/a 1075 1078
low_complexity n/a 1112 1134
disorder n/a 1117 1121
disorder n/a 1123 1135
disorder n/a 1143 1162
Pfam Ion_trans 1205 1478
transmembrane n/a 1207 1225
transmembrane n/a 1246 1268
transmembrane n/a 1274 1294
low_complexity n/a 1302 1317
transmembrane n/a 1323 1349
transmembrane n/a 1444 1468
Pfam Ion_trans 1525 1782
transmembrane n/a 1527 1545
transmembrane n/a 1557 1575
transmembrane n/a 1587 1607
transmembrane n/a 1613 1632
low_complexity n/a 1623 1635
transmembrane n/a 1644 1672
disorder n/a 1733 1734
low_complexity n/a 1745 1763
transmembrane n/a 1748 1771
disorder n/a 1889 1893
disorder n/a 1944 2000
low_complexity n/a 1961 1969
low_complexity n/a 1975 1991

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9NY46. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK
50
51
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVMNKGKAIF
100
101
RFSATSALYI LTPLNPVRKI AIKILVHSLF SMLIMCTILT NCVFMTLSNP
150
151
PDWTKNVEYT FTGIYTFESL IKILARGFCL EDFTFLRDPW NWLDFSVIVM
200
201
AYVTEFVSLG NVSALRTFRV LRALKTISVI PGLKTIVGAL IQSVKKLSDV
250
251
MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD
300
301
SNGTFVNVTM STFNWKDYIG DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY
350
351
ICVKAGRNPN YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY
400
401
MIFFVLVIFL GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE
450
451
QLKKQQEEAQ AVAAASAASR DFSGIGGLGE LLESSSEASK LSSKSAKEWR
500
501
NRRKKRRQRE HLEGNNKGER DSFPKSESED SVKRSSFLFS MDGNRLTSDK
550
551
KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
600
601
FEDSESRRDS LFVPHRHGER RNSNVSQASM SSRMVPGLPA NGKMHSTVDC
650
651
NGVVSLVGGP SALTSPTGQL PPEGTTTETE VRKRRLSSYQ ISMEMLEDSS
700
701
GRQRAVSIAS ILTNTMEELE ESRQKCPPCW YRFANVFLIW DCCDAWLKVK
750
751
HLVNLIVMDP FVDLAITICI VLNTLFMAME HYPMTEQFSS VLTVGNLVFT
800
801
GIFTAEMVLK IIAMDPYYYF QEGWNIFDGI IVSLSLMELG LSNVEGLSVL
850
851
RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG
900
901
MQLFGKSYKE CVCKINDDCT LPRWHMNDFF HSFLIVFRVL CGEWIETMWD
950
951
CMEVAGQTMC LIVFMLVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE
1000
1001
MNNLQIAVGR MQKGIDYVKN KMRECFQKAF FRKPKVIEIH EGNKIDSCMS
1050
1051
NNTGIEISKE LNYLRDGNGT TSGVGTGSSV EKYVIDENDY MSFINNPSLT
1100
1101
VTVPIAVGES DFENLNTEEF SSESELEESK EKLNATSSSE GSTVDVVLPR
1150
1151
EGEQAETEPE EDLKPEACFT EGCIKKFPFC QVSTEEGKGK IWWNLRKTCY
1200
1201
SIVEHNWFET FIVFMILLSS GALAFEDIYI EQRKTIKTML EYADKVFTYI
1250
1251
FILEMLLKWV AYGFQTYFTN AWCWLDFLIV DVSLVSLVAN ALGYSELGAI
1300
1301
KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIMNVLL VCLIFWLIFS
1350
1351
IMGVNLFAGK FYHCVNMTTG NMFDISDVNN LSDCQALGKQ ARWKNVKVNF
1400
1401
DNVGAGYLAL LQVATFKGWM DIMYAAVDSR DVKLQPVYEE NLYMYLYFVI
1450
1451
FIIFGSFFTL NLFIGVIIDN FNQQKKKFGG QDIFMTEEQK KYYNAMKKLG
1500
1501
SKKPQKPIPR PANKFQGMVF DFVTRQVFDI SIMILICLNM VTMMVETDDQ
1550
1551
GKYMTLVLSR INLVFIVLFT GEFVLKLVSL RHYYFTIGWN IFDFVVVILS
1600
1601
IVGMFLAEMI EKYFVSPTLF RVIRLARIGR ILRLIKGAKG IRTLLFALMM
1650
1651
SLPALFNIGL LLFLVMFIYA IFGMSNFAYV KKEAGIDDMF NFETFGNSMI
1700
1701
CLFQITTSAG WDGLLAPILN SAPPDCDPDT IHPGSSVKGD CGNPSVGIFF
1750
1751
FVSYIIISFL VVVNMYIAVI LENFSVATEE SAEPLSEDDF EMFYEVWEKF
1800
1801
DPDATQFIEF SKLSDFAAAL DPPLLIAKPN KVQLIAMDLP MVSGDRIHCL
1850
1851
DILFAFTKRV LGESGEMDAL RIQMEDRFMA SNPSKVSYEP ITTTLKRKQE
1900
1901
EVSAAIIQRN FRCYLLKQRL KNISSNYNKE AIKGRIDLPI KQDMIIDKLN
1950
1951
GNSTPEKTDG SSSTTSPPSY DSVTKPDKEK FEKDKPEKES KGKEVRENQK
2000
2001
                                                      
2000
 

Show the unformatted sequence.

Checksums:
CRC64:F754A1C7D49ECB58
MD5:113db26488bef8383171f1c1a0b2919b

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;