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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SI1L2_HUMAN (Q9P2F8)

Summary

This is the summary of UniProt entry SI1L2_HUMAN (Q9P2F8).

Description: Signal-induced proliferation-associated 1-like protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1722 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 29
disorder n/a 32 42
disorder n/a 44 83
low_complexity n/a 57 70
disorder n/a 94 95
disorder n/a 108 132
low_complexity n/a 117 133
disorder n/a 150 162
disorder n/a 167 168
disorder n/a 171 173
disorder n/a 175 178
disorder n/a 182 183
disorder n/a 185 193
disorder n/a 195 196
disorder n/a 279 280
disorder n/a 350 397
disorder n/a 422 428
low_complexity n/a 431 448
disorder n/a 457 463
Pfam Rap_GAP 624 806
disorder n/a 624 626
Pfam PDZ 950 1022
disorder n/a 1058 1062
disorder n/a 1065 1101
low_complexity n/a 1093 1102
disorder n/a 1103 1246
low_complexity n/a 1119 1137
low_complexity n/a 1219 1237
disorder n/a 1253 1255
disorder n/a 1258 1260
disorder n/a 1269 1271
disorder n/a 1284 1285
disorder n/a 1294 1316
disorder n/a 1330 1358
low_complexity n/a 1337 1357
low_complexity n/a 1357 1366
disorder n/a 1369 1375
disorder n/a 1378 1387
disorder n/a 1398 1442
low_complexity n/a 1404 1418
Pfam SPAR_C 1419 1666
low_complexity n/a 1494 1507
disorder n/a 1495 1496
disorder n/a 1504 1505
disorder n/a 1524 1536
disorder n/a 1559 1562
low_complexity n/a 1587 1598
disorder n/a 1625 1631
disorder n/a 1635 1656
coiled_coil n/a 1658 1706
disorder n/a 1683 1684
disorder n/a 1690 1698
disorder n/a 1700 1701

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9P2F8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS
50
51
LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE
100
101
SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ
150
151
RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR
200
201
QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI
250
251
SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS
300
301
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN
350
351
VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG
400
401
KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC
450
451
TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF
500
501
GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED
550
551
AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE
600
601
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF
650
651
SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR
700
701
HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG
750
751
VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM
800
801
ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF
850
851
SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV
900
901
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE
950
951
MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA
1000
1001
TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE
1050
1051
GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ
1100
1101
AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP
1150
1151
LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ
1200
1201
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP
1250
1251
ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA
1300
1301
ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG
1350
1351
SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW
1400
1401
KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK
1450
1451
EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS
1500
1501
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD
1550
1551
GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH
1600
1601
HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS
1650
1651
PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES
1700
1701
QTATAQLRKF TEWFFTTIDK KS                              
1722
 

Show the unformatted sequence.

Checksums:
CRC64:C99E808CD6B156B1
MD5:4e53de251a74704999752663c3d7dee7

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;