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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: POK18_HUMAN (Q9QC07)

Summary

This is the summary of UniProt entry POK18_HUMAN (Q9QC07).

Description: Endogenous retrovirus group K member 18 Pol protein Reverse transcriptase Ribonuclease H EC=2.7.7.49 EC=3.1.26.4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 812 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 10 12
Pfam RVT_1 76 245
Pfam RVT_thumb 252 317
Pfam RNase_H 461 590
low_complexity n/a 540 550
Pfam Integrase_Zn 592 629
Pfam rve 646 739
disorder n/a 754 761
disorder n/a 763 765
disorder n/a 795 812

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9QC07. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
NKSRKRRNRV SFLGVTTVEP PKPIPLTWKT EKLVWVNQWP LPKQKLEALH
50
51
LLANEQLEKG HIEPSFSPWN SPVFVIQKKS SKWRMLTDLR AVNAVIQPMG
100
101
PLQPGLPSPA MIPKDWPLII IDLKDCFFTI PLAEQDCEKF AFTIPAINNK
150
151
EPATRFQWKV LPQGMLNSPT ICQTFVGRAL QPVRDKFSDC YIIHYFDDIL
200
201
CAAETKDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY LGMQIENRKI
250
251
KPQKIEIRKD TLKTLNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
300
301
DLNSKRMLTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG
350
351
IIIQNTDLVE WSFLPHSTVK TFTLYLDQIA TLIGPTRLRI IKLCGNDPDK
400
401
IVVPLTKEQV RQAFINSGAW QIGLANFVGI IDNHYPKTKI FQFLKLTTWI
450
451
LPKITRREPL ENALTVFTDG SSNGKVAYTG PKERVIKTPY QSAQRAELVA
500
501
VITVLQDFDQ PINIISDSAY VVQATRDVET ALIKYSMDDQ LNQLFNLLQQ
550
551
TVRKRNFPFY ITHIRAHTNL PGPLTKANEQ ADLLVSSAFI KAQELHALTH
600
601
VNAAGLKNKF DVTWKQAKDI VQHCTQCQVL DLPTQEAGVN PEVCVLMHYG
650
651
KWMSHMYLHL GRLSYVHVTV DTYSHFMCAT CQTGESTSHV KKHLLSCFAV
700
701
MGVPEKIKTD NGPGYCSKAF QKFLSQWKIS HTTGIPYNSQ GQAIVERTNR
750
751
TLKTQLVKQK EGGDSKECTT PQMQLNLALY TLNFLNIYRN QTTTSAEHLT
800
801
GKKNSPHEGK LI                                         
812
 

Show the unformatted sequence.

Checksums:
CRC64:6E25F504DD1F0183
MD5:fe9d653b01edb7041fece5fdd86a7b77

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;