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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MTRR_HUMAN (Q9UBK8)

Summary

This is the summary of UniProt entry MTRR_HUMAN (Q9UBK8).

Description: Methionine synthase reductase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 698 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
Pfam Flavodoxin_1 6 142
disorder n/a 67 71
disorder n/a 165 168
disorder n/a 205 209
low_complexity n/a 208 219
Pfam FAD_binding_1 267 492
low_complexity n/a 418 429
low_complexity n/a 435 449
Pfam NAD_binding_1 542 662

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UBK8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRRFLLLYAT QQGQAKAIAE EICEQAVVHG FSADLHCISE SDKYDLKTET
50
51
APLVVVVSTT GTGDPPDTAR KFVKEIQNQT LPVDFFAHLR YGLLGLGDSE
100
101
YTYFCNGGKI IDKRLQELGA RHFYDTGHAD DCVGLELVVE PWIAGLWPAL
150
151
RKHFRSSRGQ EEISGALPVA SPASSRTDLV KSELLHIESQ VELLRFDDSG
200
201
RKDSEVLKQN AVNSNQSNVV IEDFESSLTR SVPPLSQASL NIPGLPPEYL
250
251
QVHLQESLGQ EESQVSVTSA DPVFQVPISK AVQLTTNDAI KTTLLVELDI
300
301
SNTDFSYQPG DAFSVICPNS DSEVQSLLQR LQLEDKREHC VLLKIKADTK
350
351
KKGATLPQHI PAGCSLQFIF TWCLEIRAIP KKAFLRALVD YTSDSAEKRR
400
401
LQELCSKQGA ADYSRFVRDA CACLLDLLLA FPSCQPPLSL LLEHLPKLQP
450
451
RPYSCASSSL FHPGKLHFVF NIVEFLSTAT TEVLRKGVCT GWLALLVASV
500
501
LQPNIHASHE DSGKALAPKI SISPRTTNSF HLPDDPSIPI IMVGPGTGIA
550
551
PFIGFLQHRE KLQEQHPDGN FGAMWLFFGC RHKDRDYLFR KELRHFLKHG
600
601
ILTHLKVSFS RDAPVGEEEA PAKYVQDNIQ LHGQQVARIL LQENGHIYVC
650
651
GDAKNMAKDV HDALVQIISK EVGVEKLEAM KTLATLKEEK RYLQDIWS  
698
 

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Checksums:
CRC64:D4B394F0B24A07E5
MD5:3b6f8f607e02dbd092bc3d9d6f6e118c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FAD_binding_1 272 - 492 2QTL A 272 - 492 Jmol OpenAstexViewer
2QTZ A 272 - 492 Jmol OpenAstexViewer
NAD_binding_1 542 - 662 2QTL A 542 - 662 Jmol OpenAstexViewer
2QTZ A 542 - 662 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.