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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CATZ_HUMAN (Q9UBR2)

Summary

This is the summary of UniProt entry CATZ_HUMAN (Q9UBR2).

Description: Cathepsin Z
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 303 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
low_complexity n/a 10 24
Pfam Peptidase_C1 62 296

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UBR2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY
50
51
PRPHEYLSPA DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA
100
101
MADRINIKRK GAWPSTLLSV QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP
150
151
DETCNNYQAK DQECDKFNQC GTCNEFKECH AIRNYTLWRV GDYGSLSGRE
200
201
KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN HVVSVAGWGI
250
251
SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD
300
301
PIV                                                   
303
 

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Checksums:
CRC64:6274FD1974D0EBDC
MD5:538594a9a24f25480b8b43c2afb76a05

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_C1 62 - 296 1DEU A 1 - 235 Jmol OpenAstexViewer
B 1 - 235 Jmol OpenAstexViewer
1EF7 A 1 - 235 Jmol OpenAstexViewer
B 1 - 235 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.