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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NXF1_HUMAN (Q9UBU9)

Summary

This is the summary of UniProt entry NXF1_HUMAN (Q9UBU9).

Description: Nuclear RNA export factor 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 619 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 114
low_complexity n/a 35 50
Pfam Tap-RNA_bind 116 198
low_complexity n/a 183 193
low_complexity n/a 266 279
Pfam NTF2 386 536
disorder n/a 546 571
low_complexity n/a 550 564
Pfam TAP_C 569 617

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UBU9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS
50
51
RLEEDDGDVA MSDAQDGPRV RYNPYTTRPN RRGDTWHDRD RIHVTVRRDR
100
101
APPERGGAGT SQDGTSKNWF KITIPYGRKY DKAWLLSMIQ SKCSVPFTPI
150
151
EFHYENTRAQ FFVEDASTAS ALKAVNYKIL DRENRRISII INSSAPPHTI
200
201
LNELKPEQVE QLKLIMSKRY DGSQQALDLK GLRSDPDLVA QNIDVVLNRR
250
251
SCMAATLRII EENIPELLSL NLSNNRLYRL DDMSSIVQKA PNLKILNLSG
300
301
NELKSERELD KIKGLKLEEL WLDGNSLCDT FRDQSTYISA IRERFPKLLR
350
351
LDGHELPPPI AFDVEAPTTL PPCKGSYFGT ENLKSLVLHF LQQYYAIYDS
400
401
GDRQGLLDAY HDGACCSLSI PFIPQNPARS SLAEYFKDSR NVKKLKDPTL
450
451
RFRLLKHTRL NVVAFLNELP KTQHDVNSFV VDISAQTSTL LCFSVNGVFK
500
501
EVDGKSRDSL RAFTRTFIAV PASNSGLCIV NDELFVRNAS SEEIQRAFAM
550
551
PAPTPSSSPV PTLSPEQQEM LQAFSTQSGM NLEWSQKCLQ DNNWDYTRSA
600
601
QAFTHLKAKG EIPEVAFMK                                  
619
 

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Checksums:
CRC64:338872AADA789FBF
MD5:e5ee0510d5e5b21769ec2369323734ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NTF2 386 - 536 1JKG B 386 - 536 Jmol OpenAstexViewer
1JN5 B 386 - 536 Jmol OpenAstexViewer
4WYK A 386 - 536 Jmol OpenAstexViewer
C 386 - 536 Jmol OpenAstexViewer
6E5U A 386 - 536 Jmol OpenAstexViewer
C 386 - 536 Jmol OpenAstexViewer
E 386 - 536 Jmol OpenAstexViewer
G 386 - 536 Jmol OpenAstexViewer
Tap-RNA_bind 116 - 198 1KOH A 116 - 198 Jmol OpenAstexViewer
C 116 - 198 Jmol OpenAstexViewer
1KOO A 116 - 198 Jmol OpenAstexViewer
C 116 - 198 Jmol OpenAstexViewer
117 - 198 1FT8 C 117 - 198 Jmol OpenAstexViewer
3RW6 B 117 - 198 Jmol OpenAstexViewer
3RW7 C 117 - 198 Jmol OpenAstexViewer
118 - 198 1FT8 A 118 - 198 Jmol OpenAstexViewer
3RW6 A 118 - 198 Jmol OpenAstexViewer
3RW7 A 118 - 198 Jmol OpenAstexViewer
119 - 175 1FT8 E 119 - 175 Jmol OpenAstexViewer
123 - 191 1FO1 A 123 - 191 Jmol OpenAstexViewer
TAP_C 569 - 617 1GO5 A 20 - 68 Jmol OpenAstexViewer
1OAI A 569 - 617 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.