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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: COE1_HUMAN (Q9UH73)

Summary

This is the summary of UniProt entry COE1_HUMAN (Q9UH73).

Description: Transcription factor COE1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 591 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 11 22
Pfam COE1_DBD 17 247
disorder n/a 48 50
disorder n/a 53 55
disorder n/a 239 251
Pfam TIG 262 344
Pfam COE1_HLH 347 390
disorder n/a 373 374
disorder n/a 423 427
disorder n/a 450 487
disorder n/a 492 493
disorder n/a 517 518
disorder n/a 520 522
disorder n/a 526 529
low_complexity n/a 526 538
low_complexity n/a 532 544
disorder n/a 554 579
low_complexity n/a 564 575

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UH73. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA
50
51
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN
100
101
SEKTNNGIHY RLQLLYSNGI RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM
150
151
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
200
201
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
250
251
EGTPSYLEHA TPCIKAISPS EGWTTGGATV IIIGDNFFDG LQVIFGTMLV
300
301
WSELITPHAI RVQTPPRHIP GVVEVTLSYK SKQFCKGTPG RFIYTALNEP
350
351
TIDYGFQRLQ KVIPRHPGDP ERLPKEVILK RAADLVEALY GMPHNNQEII
400
401
LKRAADIAEA LYSVPRNHNQ LPALANTSVH AGMMGVNSFS GQLAVNVSEA
450
451
SQATNQGFTR NSSSVSPHGY VPSTTPQQTN YNSVTTSMNG YGSAAMSNLG
500
501
GSPTFLNGSA ANSPYAIVPS SPTMASSTSL PSNCSSSSGI FSFSPANMVS
550
551
AVKQKSAFAP VVRPQTSPPP TCTSTNGNSL QAISGMIVPP M         
591
 

Show the unformatted sequence.

Checksums:
CRC64:E47797B6FC1E5071
MD5:24d6a365fa56039289df2d2c1000ab90

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
COE1_DBD 21 - 237 3LYR A 21 - 237 Show 3D Structure View in InterPro
COE1_HLH 347 - 348 3MQI A 347 - 348 Show 3D Structure View in InterPro
B 347 - 348 Show 3D Structure View in InterPro
TIG 262 - 344 3MQI A 262 - 344 Show 3D Structure View in InterPro
B 262 - 344 Show 3D Structure View in InterPro
C 262 - 344 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;