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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AFF4_HUMAN (Q9UHB7)

Summary

This is the summary of UniProt entry AFF4_HUMAN (Q9UHB7).

Description: AF4/FMR2 family member 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1163 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 907
Pfam AF-4 2 1159
low_complexity n/a 128 142
low_complexity n/a 135 147
low_complexity n/a 167 184
low_complexity n/a 187 196
low_complexity n/a 375 392
low_complexity n/a 423 451
low_complexity n/a 450 467
low_complexity n/a 567 576
low_complexity n/a 626 639
low_complexity n/a 644 662
low_complexity n/a 693 707
low_complexity n/a 835 886
low_complexity n/a 881 893
disorder n/a 909 910
coiled_coil n/a 915 935
disorder n/a 919 920
disorder n/a 963 964
disorder n/a 1033 1040
disorder n/a 1043 1066
low_complexity n/a 1061 1081
disorder n/a 1068 1073

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UHB7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNREDRNVLR MKERERRNQE IQQGEDAFPP SSPLFAEPYK VTSKEDKLSS
50
51
RIQSMLGNYD EMKDFIGDRS IPKLVAIPKP TVPPSADEKS NPNFFEQRHG
100
101
GSHQSSKWTP VGPAPSTSQS QKRSSGLQSG HSSQRTSAGS SSGTNSSGQR
150
151
HDRESYNNSG SSSRKKGQHG SEHSKSRSSS PGKPQAVSSL NSSHSRSHGN
200
201
DHHSKEHQRS KSPRDPDANW DSPSRVPFSS GQHSTQSFPP SLMSKSNSML
250
251
QKPTAYVRPM DGQESMEPKL SSEHYSSQSH GNSMTELKPS SKAHLTKLKI
300
301
PSQPLDASAS GDVSCVDEIL KEMTHSWPPP LTAIHTPCKT EPSKFPFPTK
350
351
ESQQSNFGTG EQKRYNPSKT SNGHQSKSML KDDLKLSSSE DSDGEQDCDK
400
401
TMPRSTPGSN SEPSHHNSEG ADNSRDDSSS HSGSESSSGS DSESESSSSD
450
451
SEANEPSQSA SPEPEPPPTN KWQLDNWLNK VNPHKVSPAS SVDSNIPSSQ
500
501
GYKKEGREQG TGNSYTDTSG PKETSSATPG RDSKTIQKGS ESGRGRQKSP
550
551
AQSDSTTQRR TVGKKQPKKA EKAAAEEPRG GLKIESETPV DLASSMPSSR
600
601
HKAATKGSRK PNIKKESKSS PRPTAEKKKY KSTSKSSQKS REIIETDTSS
650
651
SDSDESESLP PSSQTPKYPE SNRTPVKPSS VEEEDSFFRQ RMFSPMEEKE
700
701
LLSPLSEPDD RYPLIVKIDL NLLTRIPGKP YKETEPPKGE KKNVPEKHTR
750
751
EAQKQASEKV SNKGKRKHKN EDDNRASESK KPKTEDKNSA GHKPSSNRES
800
801
SKQSAAKEKD LLPSPAGPVP SKDPKTEHGS RKRTISQSSS LKSSSNSNKE
850
851
TSGSSKNSSS TSKQKKTEGK TSSSSKEVKE KAPSSSSNCP PSAPTLDSSK
900
901
PRRTKLVFDD RNYSADHYLQ EAKKLKHNAD ALSDRFEKAV YYLDAVVSFI
950
951
ECGNALEKNA QESKSPFPMY SETVDLIKYT MKLKNYLAPD ATAADKRLTV
1000
1001
LCLRCESLLY LRLFKLKKEN ALKYSKTLTE HLKNSYNNSQ APSPGLGSKA
1050
1051
VGMPSPVSPK LSPGNSGNYS SGASSASASG SSVTIPQKIH QMAASYVQVT
1100
1101
SNFLYATEIW DQAEQLSKEQ KEFFAELDKV MGPLIFNASI MTDLVRYTRQ
1150
1151
GLHWLRQDAK LIS                                        
1163
 

Show the unformatted sequence.

Checksums:
CRC64:474E1906B8832AC1
MD5:9aa14d271a4c04d13059eb5995757698

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AF-4 3 - 67 4IMY H 3 - 67 Jmol OpenAstexViewer
314 - 349 5JW9 A 14 - 49 Jmol OpenAstexViewer
32 - 69 4OR5 E 32 - 69 Jmol OpenAstexViewer
J 32 - 69 Jmol OpenAstexViewer
34 - 66 4IMY G 34 - 66 Jmol OpenAstexViewer
I 34 - 66 Jmol OpenAstexViewer
34 - 67 5L1Z C 34 - 67 Jmol OpenAstexViewer
34 - 69 4OGR G 34 - 69 Jmol OpenAstexViewer
4 - 69 4OGR C 4 - 69 Jmol OpenAstexViewer
L 4 - 69 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.