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22  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TBK1_HUMAN (Q9UHD2)

Summary

This is the summary of UniProt entry TBK1_HUMAN (Q9UHD2).

Description: Serine/threonine-protein kinase TBK1 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 729 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Pkinase 9 299
Pfam TBK1_ULD 308 395
Pfam TBK1_CCD1 400 655
disorder n/a 537 538

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UHD2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD
50
51
VQMREFEVLK KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE
100
101
PSNAYGLPES EFLIVLRDVV GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ
150
151
SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKDHQKKYGA
200
201
TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG KPSGAISGVQ
250
251
KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA
300
301
ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ
350
351
ELIYEGRRLV LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP
400
401
KVHPRYDLDG DASMAKAITG VVCYACRIAS TLLLYQELMR KGIRWLIELI
450
451
KDDYNETVHK KTEVVITLDF CIRNIEKTVK VYEKLMKINL EAAELGEISD
500
501
IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE GTHPKDRNVE
550
551
KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH
600
601
FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY
650
651
TNELQETLPQ KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV
700
701
VKELAENNHI LERFGSLTMD GGLRNVDCL                       
729
 

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Checksums:
CRC64:B58E4FE1B502276D
MD5:ea019cf79d039a451dece6c8a25e0050

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 9 - 299 4EUT A 9 - 299 NGL View in InterPro
B 9 - 299 NGL View in InterPro
4EUU A 9 - 299 NGL View in InterPro
B 9 - 299 NGL View in InterPro
4IM0 A 9 - 299 NGL View in InterPro
4IM2 A 9 - 299 NGL View in InterPro
4IM3 A 9 - 299 NGL View in InterPro
4IW0 A 9 - 299 NGL View in InterPro
4IWO A 9 - 299 NGL View in InterPro
4IWP A 9 - 299 NGL View in InterPro
4IWQ A 9 - 299 NGL View in InterPro
5W5V A 9 - 299 NGL View in InterPro
6BNY A 9 - 299 NGL View in InterPro
6BOD A 9 - 299 NGL View in InterPro
6BOE A 9 - 299 NGL View in InterPro
6CQ0 A 9 - 299 NGL View in InterPro
6CQ4 A 9 - 299 NGL View in InterPro
6CQ5 A 9 - 299 NGL View in InterPro
6NT9 A 9 - 299 NGL View in InterPro
B 9 - 299 NGL View in InterPro
6O8B A 9 - 299 NGL View in InterPro
B 9 - 299 NGL View in InterPro
6RSR A 9 - 299 NGL View in InterPro
6RST A 9 - 299 NGL View in InterPro
6RSU A 9 - 299 NGL View in InterPro
TBK1_CCD1 400 - 654 6O8B B 400 - 654 NGL View in InterPro
400 - 655 4IM0 A 400 - 655 NGL View in InterPro
4IM2 A 400 - 655 NGL View in InterPro
4IM3 A 400 - 655 NGL View in InterPro
4IW0 A 400 - 655 NGL View in InterPro
4IWO A 400 - 655 NGL View in InterPro
4IWP A 400 - 655 NGL View in InterPro
4IWQ A 400 - 655 NGL View in InterPro
5W5V A 400 - 655 NGL View in InterPro
6BNY A 400 - 655 NGL View in InterPro
6BOD A 400 - 655 NGL View in InterPro
6BOE A 400 - 655 NGL View in InterPro
6CQ0 A 400 - 655 NGL View in InterPro
6CQ4 A 400 - 655 NGL View in InterPro
6CQ5 A 400 - 655 NGL View in InterPro
6NT9 A 400 - 655 NGL View in InterPro
B 400 - 655 NGL View in InterPro
6O8B A 400 - 655 NGL View in InterPro
6RSR A 400 - 655 NGL View in InterPro
6RST A 400 - 655 NGL View in InterPro
6RSU A 400 - 655 NGL View in InterPro
TBK1_ULD 308 - 383 4EFO A 308 - 383 NGL View in InterPro
B 308 - 383 NGL View in InterPro
308 - 385 4EUT A 308 - 385 NGL View in InterPro
B 308 - 385 NGL View in InterPro
308 - 395 4IM0 A 308 - 395 NGL View in InterPro
4IM2 A 308 - 395 NGL View in InterPro
4IM3 A 308 - 395 NGL View in InterPro
4IW0 A 308 - 395 NGL View in InterPro
4IWO A 308 - 395 NGL View in InterPro
4IWP A 308 - 395 NGL View in InterPro
4IWQ A 308 - 395 NGL View in InterPro
5W5V A 308 - 395 NGL View in InterPro
6BNY A 308 - 395 NGL View in InterPro
6BOD A 308 - 395 NGL View in InterPro
6BOE A 308 - 395 NGL View in InterPro
6CQ0 A 308 - 395 NGL View in InterPro
6CQ4 A 308 - 395 NGL View in InterPro
6CQ5 A 308 - 395 NGL View in InterPro
6NT9 A 308 - 395 NGL View in InterPro
B 308 - 395 NGL View in InterPro
6O8B A 308 - 395 NGL View in InterPro
B 308 - 395 NGL View in InterPro
6RSR A 308 - 395 NGL View in InterPro
6RST A 308 - 395 NGL View in InterPro
6RSU A 308 - 395 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.