Summary
This is the summary of UniProt entry MED13_HUMAN (Q9UHV7).
| Description: | Mediator of RNA polymerase II transcription subunit 13 {ECO:0000305} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 2174 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 256 | 258 |
| disorder | n/a | 316 | 339 |
| disorder | n/a | 357 | 371 |
| disorder | n/a | 378 | 383 |
| disorder | n/a | 386 | 400 |
| disorder | n/a | 426 | 587 |
| low_complexity | n/a | 438 | 451 |
| low_complexity | n/a | 531 | 540 |
| disorder | n/a | 597 | 599 |
| disorder | n/a | 601 | 602 |
| disorder | n/a | 630 | 646 |
| coiled_coil | n/a | 672 | 692 |
| disorder | n/a | 693 | 697 |
| disorder | n/a | 709 | 736 |
| disorder | n/a | 738 | 740 |
| disorder | n/a | 746 | 771 |
| disorder | n/a | 783 | 813 |
| disorder | n/a | 841 | 848 |
| disorder | n/a | 851 | 870 |
| disorder | n/a | 954 | 1039 |
| low_complexity | n/a | 987 | 999 |
| low_complexity | n/a | 1002 | 1030 |
| disorder | n/a | 1047 | 1050 |
| disorder | n/a | 1052 | 1059 |
| low_complexity | n/a | 1184 | 1195 |
| Pfam | MID_MedPIWI | 1367 | 1724 |
| low_complexity | n/a | 1462 | 1479 |
| disorder | n/a | 1480 | 1481 |
| disorder | n/a | 1483 | 1510 |
| low_complexity | n/a | 1499 | 1518 |
| low_complexity | n/a | 1523 | 1553 |
| disorder | n/a | 1531 | 1629 |
| Pfam | Med13_C | 1760 | 2163 |
| low_complexity | n/a | 1827 | 1837 |
| disorder | n/a | 1941 | 1949 |
| disorder | n/a | 1982 | 1985 |
| disorder | n/a | 1996 | 1999 |
| low_complexity | n/a | 1999 | 2010 |
| low_complexity | n/a | 2005 | 2016 |
| disorder | n/a | 2011 | 2019 |
| disorder | n/a | 2022 | 2053 |
| disorder | n/a | 2113 | 2118 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UHV7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSASFVPNGA SLEDCHCNLF CLADLTGIKW KKYVWQGPTS APILFPVTEE
50 51
DPILSSFSRC LKADVLGVWR RDQRPGRREL WIFWWGEDPS FADLIHHDLS
100 101
EEEDGVWENG LSYECRTLLF KAVHNLLERC LMNRNFVRIG KWFVKPYEKD
150 151
EKPINKSEHL SCSFTFFLHG DSNVCTSVEI NQHQPVYLLS EEHITLAQQS
200 201
NSPFQVILCP FGLNGTLTGQ AFKMSDSATK KLIGEWKQFY PISCCLKEMS
250 251
EEKQEDMDWE DDSLAAVEVL VAGVRMIYPA CFVLVPQSDI PTPSPVGSTH
300 301
CSSSCLGVHQ VPASTRDPAM SSVTLTPPTS PEEVQTVDPQ SVQKWVKFSS
350 351
VSDGFNSDST SHHGGKIPRK LANHVVDRVW QECNMNRAQN KRKYSASSGG
400 401
LCEEATAAKV ASWDFVEATQ RTNCSCLRHK NLKSRNAGQQ GQAPSLGQQQ
450 451
QILPKHKTNE KQEKSEKPQK RPLTPFHHRV SVSDDVGMDA DSASQRLVIS
500 501
APDSQVRFSN IRTNDVAKTP QMHGTEMANS PQPPPLSPHP CDVVDEGVTK
550 551
TPSTPQSQHF YQMPTPDPLV PSKPMEDRID SLSQSFPPQY QEAVEPTVYV
600 601
GTAVNLEEDE ANIAWKYYKF PKKKDVEFLP PQLPSDKFKD DPVGPFGQES
650 651
VTSVTELMVQ CKKPLKVSDE LVQQYQIKNQ CLSAIASDAE QEPKIDPYAF
700 701
VEGDEEFLFP DKKDRQNSER EAGKKHKVED GTSSVTVLSH EEDAMSLFSP
750 751
SIKQDAPRPT SHARPPSTSL IYDSDLAVSY TDLDNLFNSD EDELTPGSKK
800 801
SANGSDDKAS CKESKTGNLD PLSCISTADL HKMYPTPPSL EQHIMGFSPM
850 851
NMNNKEYGSM DTTPGGTVLE GNSSSIGAQF KIEVDEGFCS PKPSEIKDFS
900 901
YVYKPENCQI LVGCSMFAPL KTLPSQYLPP IKLPEECIYR QSWTVGKLEL
950 951
LSSGPSMPFI KEGDGSNMDQ EYGTAYTPQT HTSFGMPPSS APPSNSGAGI
1000 1001
LPSPSTPRFP TPRTPRTPRT PRGAGGPASA QGSVKYENSD LYSPASTPST
1050 1051
CRPLNSVEPA TVPSIPEAHS LYVNLILSES VMNLFKDCNF DSCCICVCNM
1100 1101
NIKGADVGVY IPDPTQEAQY RCTCGFSAVM NRKFGNNSGL FLEDELDIIG
1150 1151
RNTDCGKEAE KRFEALRATS AEHVNGGLKE SEKLSDDLIL LLQDQCTNLF
1200 1201
SPFGAADQDP FPKSGVISNW VRVEERDCCN DCYLALEHGR QFMDNMSGGK
1250 1251
VDEALVKSSC LHPWSKRNDV SMQCSQDILR MLLSLQPVLQ DAIQKKRTVR
1300 1301
PWGVQGPLTW QQFHKMAGRG SYGTDESPEP LPIPTFLLGY DYDYLVLSPF
1350 1351
ALPYWERLML EPYGSQRDIA YVVLCPENEA LLNGAKSFFR DLTAIYESCR
1400 1401
LGQHRPVSRL LTDGIMRVGS TASKKLSEKL VAEWFSQAAD GNNEAFSKLK
1450 1451
LYAQVCRYDL GPYLASLPLD SSLLSQPNLV APTSQSLITP PQMTNTGNAN
1500 1501
TPSATLASAA SSTMTVTSGV AISTSVATAN STLTTASTSS SSSSNLNSGV
1550 1551
SSNKLPSFPP FGSMNSNAAG SMSTQANTVQ SGQLGGQQTS ALQTAGISGE
1600 1601
SSSLPTQPHP DVSESTMDRD KVGIPTDGDS HAVTYPPAIV VYIIDPFTYE
1650 1651
NTDESTNSSS VWTLGLLRCF LEMVQTLPPH IKSTVSVQII PCQYLLQPVK
1700 1701
HEDREIYPQH LKSLAFSAFT QCRRPLPTST NVKTLTGFGP GLAMETALRS
1750 1751
PDRPECIRLY APPFILAPVK DKQTELGETF GEAGQKYNVL FVGYCLSHDQ
1800 1801
RWILASCTDL YGELLETCII NIDVPNRARR KKSSARKFGL QKLWEWCLGL
1850 1851
VQMSSLPWRV VIGRLGRIGH GELKDWSCLL SRRNLQSLSK RLKDMCRMCG
1900 1901
ISAADSPSIL SACLVAMEPQ GSFVIMPDSV STGSVFGRST TLNMQTSQLN
1950 1951
TPQDTSCTHI LVFPTSASVQ VASATYTTEN LDLAFNPNND GADGMGIFDL
2000 2001
LDTGDDLDPD IINILPASPT GSPVHSPGSH YPHGGDAGKG QSTDRLLSTE
2050 2051
PHEEVPNILQ QPLALGYFVS TAKAGPLPDW FWSACPQAQY QCPLFLKASL
2100 2101
HLHVPSVQSD ELLHSKHSHP LDSNQTSDVL RFVLEQYNAL SWLTCDPATQ
2150 2151
DRRSCLPIHF VVLNQLYNFI MNML
2174
Show the unformatted sequence. |
| Checksums: |
CRC64:0FA54C84FE2C91E2
MD5:f477776e4ccf295fa175dcd23bb9df56
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
