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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: M2GD_HUMAN (Q9UI17)

Summary

This is the summary of UniProt entry M2GD_HUMAN (Q9UI17).

Description: Dimethylglycine dehydrogenase, mitochondrial
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 866 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 1 19
disorder n/a 24 43
Pfam DAO 51 414
disorder n/a 226 228
disorder n/a 230 233
Pfam FAO_M 417 471
Pfam GCV_T 474 745
Pfam GCV_T_C 770 848
disorder n/a 853 866

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UI17. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLRPGAQLLR GLLLRSCPLQ GSPGRPRSVC GREGEEKPPL SAETQWKDRA
50
51
ETVIIGGGCV GVSLAYHLAK AGMKDVVLLE KSELTAGSTW HAAGLTTYFH
100
101
PGINLKKIHY DSIKLYEKLE EETGQVVGFH QPGSIRLATT PVRVDEFKYQ
150
151
MTRTGWHATE QYLIEPEKIQ EMFPLLNMNK VLAGLYNPGD GHIDPYSLTM
200
201
ALAAGARKCG ALLKYPAPVT SLKARSDGTW DVETPQGSMR ANRIVNAAGF
250
251
WAREVGKMIG LEHPLIPVQH QYVVTSTISE VKALKRELPV LRDLEGSYYL
300
301
RQERDGLLFG PYESQEKMKV QDSWVTNGVP PGFGKELFES DLDRIMEHIK
350
351
AAMEMVPVLK KADIINVVNG PITYSPDILP MVGPHQGVRN YWVAIGFGYG
400
401
IIHAGGVGKY LSDWILHGEP PFDLIELDPN RYGKWTTTQY TEAKARESYG
450
451
FNNIVGYPKE ERFAGRPTQR VSGLYQRLES KCSMGFHAGW EQPHWFYKPG
500
501
QDTQYRPSFR RTNWFEPVGS EYKQVMQRVA VTDLSPFGKF NIKGQDSIRL
550
551
LDHLFANVIP KVGFTNISHM LTPKGRVYAE LTVSHQSPGE FLLITGSGSE
600
601
LHDLRWIEEE AVKGGYDVEI KNITDELGVL GVAGPQARKV LQKLTSEDLS
650
651
DDVFKFLQTK SLKVSNIPVT AIRISYTGEL GWELYHRRED SVALYDAIMN
700
701
AGQEEGIDNF GTYAMNALRL EKAFRAWGLE MNCDTNPLEA GLEYFVKLNK
750
751
PADFIGKQAL KQIKAKGLKR RLVCLTLATD DVDPEGNESI WYNGKVVGNT
800
801
TSGSYSYSIQ KSLAFAYVPV QLSEVGQQVE VELLGKNYPA VIIQEPLVLT
850
851
EPTRNRLQKK GGKDKT                                     
866
 

Show the unformatted sequence.

Checksums:
CRC64:2EC1FA7DCB6C1F8C
MD5:ee8e8fea16bc5d84d365cccd4bad45f4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DAO 51 - 414 5L46 A 51 - 414 Jmol OpenAstexViewer
B 51 - 414 Jmol OpenAstexViewer
FAO_M 417 - 471 5L46 A 417 - 471 Jmol OpenAstexViewer
B 417 - 471 Jmol OpenAstexViewer
GCV_T 474 - 745 5L46 A 474 - 745 Jmol OpenAstexViewer
B 474 - 745 Jmol OpenAstexViewer
GCV_T_C 770 - 848 5L46 A 770 - 848 Jmol OpenAstexViewer
B 770 - 848 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.