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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DBNL_HUMAN (Q9UJU6)

Summary

This is the summary of UniProt entry DBNL_HUMAN (Q9UJU6).

Description: Drebrin-like protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 430 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Cofilin_ADF 12 131
disorder n/a 44 45
low_complexity n/a 44 56
disorder n/a 126 128
disorder n/a 143 167
disorder n/a 178 180
low_complexity n/a 181 227
disorder n/a 182 367
coiled_coil n/a 182 227
low_complexity n/a 326 341
Pfam SH3_9 378 427
disorder n/a 393 396

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UJU6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL
50
51
EEMVEELNSG KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH
100
101
VSTMASFLKG AHVTINARAE EDVEPECIME KVAKASGANY SFHKESGRFQ
150
151
DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW AKAEKEEENR RLEEKRRAEE
200
201
AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ QEVVSRNRNE
250
251
QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE
300
301
PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV
350
351
QQQGAGSEHI DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG
400
401
IEVIDEGWWR GYGPDGHFGM FPANYVELIE                      
430
 

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Checksums:
CRC64:7E8C42ED047257AE
MD5:3259939e9c153de52cbd43841f4ee423

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cofilin_ADF 12 - 131 1X67 A 19 - 138 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;