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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TRPC5_HUMAN (Q9UL62)

Summary

This is the summary of UniProt entry TRPC5_HUMAN (Q9UL62).

Description: Short transient receptor potential channel 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 973 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam Ank_2 36 129
low_complexity n/a 73 91
Pfam TRP_2 176 238
low_complexity n/a 178 187
low_complexity n/a 202 213
coiled_coil n/a 227 247
transmembrane n/a 327 351
Pfam Ion_trans 363 636
transmembrane n/a 363 382
transmembrane n/a 402 419
transmembrane n/a 440 460
transmembrane n/a 480 499
low_complexity n/a 484 496
transmembrane n/a 520 542
transmembrane n/a 571 587
transmembrane n/a 599 621
low_complexity n/a 685 702
disorder n/a 687 696
disorder n/a 737 741
disorder n/a 768 793
disorder n/a 810 835
low_complexity n/a 841 852
disorder n/a 859 864
disorder n/a 905 906
low_complexity n/a 918 943
disorder n/a 968 973

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9UL62. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ
50
51
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
100
101
LYAIRKEVVG AVELLLSYRR PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
150
151
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
200
201
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
250
251
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
300
301
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
350
351
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
400
401
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
450
451
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
500
501
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
550
551
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
600
601
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
650
651
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRRNLRSFT
700
701
ERNADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTHEGLTE ENFKELKQDI
750
751
SSFRYEVLDL LGNRKHPRSF STSSTELSQR DDNNDGSGGA RAKSKSVSFN
800
801
LGCKKKTCHG PPLIRTMPRS SGAQGKSKAE SSSKRSFMGP SLKKLGLLFS
850
851
KFNGHMSEPS SEPMYTISDG IVQQHCMWQD IRYSQMEKGK AEACSQSEIN
900
901
LSEVELGEVQ GAAQSSECPL ACSSSLHCAS SICSSNSKLL DSSEDVFETW
950
951
GEACDLLMHK WGDGQEEQVT TRL                             
973
 

Show the unformatted sequence.

Checksums:
CRC64:FBC8CBF17BE42166
MD5:bb10ae6c351d27c749c0ac9fbe1c3f60

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Ank_2 36 - 117 6YSN A 36 - 117 Show 3D Structure View in InterPro
B 36 - 117 Show 3D Structure View in InterPro
C 36 - 117 Show 3D Structure View in InterPro
D 36 - 117 Show 3D Structure View in InterPro
36 - 118 7D4P A 36 - 118 Show 3D Structure View in InterPro
B 36 - 118 Show 3D Structure View in InterPro
C 36 - 118 Show 3D Structure View in InterPro
D 36 - 118 Show 3D Structure View in InterPro
7D4Q A 36 - 118 Show 3D Structure View in InterPro
B 36 - 118 Show 3D Structure View in InterPro
C 36 - 118 Show 3D Structure View in InterPro
D 36 - 118 Show 3D Structure View in InterPro
7E4T A 36 - 118 Show 3D Structure View in InterPro
B 36 - 118 Show 3D Structure View in InterPro
C 36 - 118 Show 3D Structure View in InterPro
D 36 - 118 Show 3D Structure View in InterPro
Ion_trans 363 - 636 6YSN A 363 - 636 Show 3D Structure View in InterPro
B 363 - 636 Show 3D Structure View in InterPro
C 363 - 636 Show 3D Structure View in InterPro
D 363 - 636 Show 3D Structure View in InterPro
7D4P A 363 - 636 Show 3D Structure View in InterPro
B 363 - 636 Show 3D Structure View in InterPro
C 363 - 636 Show 3D Structure View in InterPro
D 363 - 636 Show 3D Structure View in InterPro
7D4Q A 363 - 636 Show 3D Structure View in InterPro
B 363 - 636 Show 3D Structure View in InterPro
C 363 - 636 Show 3D Structure View in InterPro
D 363 - 636 Show 3D Structure View in InterPro
7E4T A 363 - 636 Show 3D Structure View in InterPro
B 363 - 636 Show 3D Structure View in InterPro
C 363 - 636 Show 3D Structure View in InterPro
D 363 - 636 Show 3D Structure View in InterPro
TRP_2 176 - 238 6YSN A 176 - 238 Show 3D Structure View in InterPro
B 176 - 238 Show 3D Structure View in InterPro
C 176 - 238 Show 3D Structure View in InterPro
D 176 - 238 Show 3D Structure View in InterPro
7D4P A 176 - 238 Show 3D Structure View in InterPro
B 176 - 238 Show 3D Structure View in InterPro
C 176 - 238 Show 3D Structure View in InterPro
D 176 - 238 Show 3D Structure View in InterPro
7D4Q A 176 - 238 Show 3D Structure View in InterPro
B 176 - 238 Show 3D Structure View in InterPro
C 176 - 238 Show 3D Structure View in InterPro
D 176 - 238 Show 3D Structure View in InterPro
7E4T A 176 - 238 Show 3D Structure View in InterPro
B 176 - 238 Show 3D Structure View in InterPro
C 176 - 238 Show 3D Structure View in InterPro
D 176 - 238 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;