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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KCNH3_HUMAN (Q9ULD8)

Summary

This is the summary of UniProt entry KCNH3_HUMAN (Q9ULD8).

Description: Potassium voltage-gated channel subfamily H member 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1083 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PAS_9 31 135
coiled_coil n/a 76 96
disorder n/a 138 151
low_complexity n/a 149 162
disorder n/a 156 161
disorder n/a 189 190
disorder n/a 192 193
transmembrane n/a 215 240
Pfam Ion_trans 224 512
transmembrane n/a 260 278
transmembrane n/a 299 319
transmembrane n/a 325 343
low_complexity n/a 333 351
transmembrane n/a 355 381
low_complexity n/a 387 392
low_complexity n/a 419 433
disorder n/a 423 430
transmembrane n/a 450 468
transmembrane n/a 480 504
Pfam cNMP_binding 601 683
disorder n/a 711 899
low_complexity n/a 770 790
low_complexity n/a 844 861
coiled_coil n/a 878 905
disorder n/a 903 935
disorder n/a 950 1083
low_complexity n/a 959 980
low_complexity n/a 1010 1023
low_complexity n/a 1039 1050

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q9ULD8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
50
51
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
100
101
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDRWKETGG
150
151
GRRRYGRARS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
200
201
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
250
251
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
300
301
HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD
350
351
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ
400
401
ELARRLETPY YLVGRRPAGG NSSGQSDNCS SSSEANGTGL ELLGGPSLRS
450
451
AYITSLYFAL SSLTSVGFGN VSANTDTEKI FSICTMLIGA LMHAVVFGNV
500
501
TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE YFQATWAVNN
550
551
GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP
600
601
AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP
650
651
RREQVVKANA DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL
700
701
SYNLGAGGGS AEVDTSSLSG DNTLMSTLEE KETDGEQGPT VSPAPADEPS
750
751
SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG GRGRPGRAGA LKAEAGPSAP
800
801
PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS FRVGQSGPEC
850
851
SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ
900
901
SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ
950
951
PPAGSVLSGT WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS
1000
1001
EPPASGDLCS EPSTPASPPP SEEGARTGPA EPVSQAEATS TGEPPPGSGG
1050
1051
LALPWDPHSL EMVLIGCHGS GTVQWTQEEG TGV                  
1083
 

Show the unformatted sequence.

Checksums:
CRC64:EF35C8968D7418CC
MD5:4818b042c6242d6cbbad845e17ddfb46

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;